『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=328496)

EID=328496EID:328496, Map:0, LastModified:2017年8月10日(木) 14:36:27, Operator:[野間口 雅子], Avail:TRUE, Censor:0, Owner:[野間口 雅子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Sakai Yosuke (日) (読)
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[継承]
2. (英) Miyake Ariko (日) (読)
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[継承]
3. (英) Doi Naoya (日) (読)
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[継承]
4. (英) Sasada Hikari (日) (読)
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[継承]
5. (英) Miyazaki Yasuyuki (日) (読)
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6.足立 昭夫
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7.野間口 雅子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.微生物病原学])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Expression Profiles of Vpx/Vpr Proteins Are Co-related with the Primate Lentiviral Lineage.  (日)    [継承]
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要約 (任意): (英) Viruses of human immunodeficiency virus type 2 (HIV-2) and some simian immunodeficiency virus (SIV) lineages carry a unique accessory protein called Vpx. Vpx is essential or critical for viral replication in natural target cells such as macrophages and T lymphocytes. We have previously shown that a poly-proline motif (PPM) located at the C-terminal region of Vpx is required for its efficient expression in two strains of HIV-2 and SIVmac, and that the Vpx expression levels of the two clones are significantly different. Notably, the PPM sequence is conserved and confined to Vpx and Vpr proteins derived from certain lineages of HIV-2/SIVs. In this study, Vpx/Vpr proteins from diverse primate lentiviral lineages were experimentally and phylogenetically analyzed to obtain the general expression picture in cells. While both the level and PPM-dependency of Vpx/Vpr expression in transfected cells varied among viral strains, each viral group, based on Vpx/Vpr amino acid sequences, was found to exhibit a characteristic expression profile. Moreover, phylogenetic tree analyses on Gag and Vpx/Vpr proteins gave essentially the same results. Taken together, our study described here suggests that each primate lentiviral lineage may have developed a unique expression pattern of Vpx/Vpr proteins for adaptation to its hostile cellular and species environments in the process of viral evolution.  (日)    [継承]
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誌名 (必須): Frontiers in Microbiology (Frontiers Media S.A.)
(eISSN: 1664-302X)

ISSN (任意): 1664-302X
ISSN: 1664-302X (eISSN: 1664-302X)
Title: Frontiers in microbiology
Title(ISO): Front Microbiol
Publisher: Frontiers Media SA
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2016年 8月 3日 (平成 28年 8月 3日) [継承]
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DOI (任意): 10.3389/fmicb.2016.01211    (→Scopusで検索) [継承]
PMID (任意): 27536295    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yosuke Sakai, Ariko Miyake, Naoya Doi, Hikari Sasada, Yasuyuki Miyazaki, Akio Adachi and Masako Nomaguchi : Expression Profiles of Vpx/Vpr Proteins Are Co-related with the Primate Lentiviral Lineage., Frontiers in Microbiology, Vol.7, 2016.
欧文冊子 ● Yosuke Sakai, Ariko Miyake, Naoya Doi, Hikari Sasada, Yasuyuki Miyazaki, Akio Adachi and Masako Nomaguchi : Expression Profiles of Vpx/Vpr Proteins Are Co-related with the Primate Lentiviral Lineage., Frontiers in Microbiology, Vol.7, 2016.

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