| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
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| ○著者 (必須): | 1. | 漆原 真樹 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.小児科学]/[徳島大学.病院.診療科.小児·周産·女性科.小児科])
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 香美 祥二
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| ○題名 (必須): | □ | (英) Role of the intrarenal renin-angiotensin system in the progression of renal disease. (日)
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| ○要約 (任意): | □ | (英) The intrarenal renin-angiotensin system (RAS) has many well-documented pathophysiologic functions in both blood pressure regulation and renal disease development. Angiotensin II (Ang II) is the major bioactive product of the RAS. It induces inflammation, renal cell growth, mitogenesis, apoptosis, migration, and differentiation. In addition, Ang II regulates the gene expression of bioactive substances and activates multiple intracellular signaling pathways that are involved in renal damage. Activation of the Ang II type 1 (AT1) receptor pathway results in the production of proinflammatory mediators, intracellular formation of reactive oxygen species, cell proliferation, and extracellular matrix synthesis, which in turn facilities renal injury. Involvement of angiotensinogen (AGT) in intrarenal RAS activation and development of renal disease has previously been reported. Moreover, studies have demonstrated that the urinary excretion rates of AGT provide a specific index of the intrarenal RAS status. Enhanced intrarenal AGT levels have been observed in experimental models of renal disease, supporting the concept that AGT plays an important role in the development and progression of renal disease. In this review, we focus on the role of intrarenal RAS activation in the pathophysiology of renal disease. Additionally, we explored the potential of urinary AGT as a novel biomarker of intrarenal RAS status in renal disease. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Pediatric Nephrology (International Paediatric Nephrology Association)
(pISSN: 0931-041X, eISSN: 1432-198X)
| ○ISSN (任意): | □ | 1432-198X
ISSN: 0931-041X
(pISSN: 0931-041X, eISSN: 1432-198X) Title: Pediatric nephrology (Berlin, Germany)Title(ISO): Pediatr NephrolSupplier: Springer Online Journal ArchivePublisher: Springer (NLM Catalog)
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| ○巻 (必須): | □ | 32
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | 1471 1479
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 7月 5日 (平成 28年 7月 5日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s00467-016-3449-7 (→Scopusで検索)
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| ○PMID (任意): | □ | 27380400 (→Scopusで検索)
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| ○Scopus (任意): | 1. | 2-s2.0-84977126881
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Review (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Chronic kidney disease (日)
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| 4. | (英) KeywordList.Keyword: Diabetic nephropathy (日)
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| 5. | (英) KeywordList.Keyword: Glomerulonephritis (日)
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| 6. | (英) KeywordList.Keyword: Renal development (日)
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| 7. | (英) KeywordList.Keyword: Renin-angiotensin system (日)
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