| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 岩佐 武 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | 松崎 利也
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Tungalagsuvd Altankhuu (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Munkhzaya Munkhsaikhan (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Yiliyasi Maira (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | 加藤 剛志
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | 桑原 章
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | 苛原 稔
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Developmental changes in the hypothalamic mRNA expression levels of PACAP and its receptor PAC1 and their sensitivity to fasting in male and female rats. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The actions and responses of hypothalamic appetite regulatory and factors change markedly during the neonatal to pre-pubertal period. Pituitary adenylate cyclase-activating polypeptide (PACAP) has been found to play pivotal roles in the regulation of metabolic and nutritional status through its specific receptor PAC1. PACAP/PAC1 have anorectic roles, and their functions are regulated by leptin in adulthood. In the present study, we showed that hypothalamic PACAP mRNA expression decreases during the neonatal to pre-pubertal period (from postnatal day 10-30) in both male and female rats. During this period, hypothalamic PACAP mRNA expression was not affected by 24h fasting in either sex, while the serum leptin levels (leptin is a positive regulator of hypothalamic PACAP expression in adulthood) of both sexes were decreased by fasting. On the other hand, hypothalamic PAC1 mRNA expression did not change during the neonatal to pre-pubertal period in either sex; however, its levels were consistently higher in males than in females. Hypothalamic PAC1 mRNA expression was decreased by 24h fasting in males, but no such changes were observed in females. These results indicate while hypothalamic PACAP expression is sensitive to a negative energy state and the serum leptin level in adulthood, no such relationships are seen in the pre-pubertal period. In addition, we speculate that differences in the gonadal steroidal milieu might induce sexual dimorphism in the basal hypothalamic PAC1 mRNA level and its response to fasting. The mechanisms responsible for and the physiological effects of such changes in hypothalamic PACAP and PAC1 expression during the developmental period remain to be clarified. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Age Factors (日) (読)
| [継承] |
| 2. | (英) Analysis of Variance (日) (読)
| [継承] |
| 3. | (英) Animals (日) (読)
| [継承] |
| 4. | (英) Animals, Newborn (日) (読)
| [継承] |
| 5. | (英) Fasting (日) (読)
| [継承] |
| 6. | (英) Female (日) (読)
| [継承] |
| 7. | (英) Gene Expression Regulation, Developmental (日) (読)
| [継承] |
| 8. | (英) Hypothalamus (日) (読)
| [継承] |
| 9. | (英) Leptin (日) (読)
| [継承] |
| 10. | (英) Male (日) (読)
| [継承] |
| 11. | (英) Pituitary Adenylate Cyclase-Activating Polypeptide (日) (読)
| [継承] |
| 12. | (英) Pregnancy (日) (読)
| [継承] |
| 13. | (英) RNA, Messenger (日) (読)
| [継承] |
| 14. | (英) Rats (日) (読)
| [継承] |
| 15. | (英) Rats, Sprague-Dawley (日) (読)
| [継承] |
| 16. | (英) Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I (日) (読)
| [継承] |
| 17. | (英) Sex Characteristics (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | International Journal of Developmental Neuroscience (International Society for Developmental Neuroscience)
(pISSN: 0736-5748, eISSN: 1873-474X)
| ○ISSN (任意): | □ | 1873-474X
ISSN: 0736-5748
(pISSN: 0736-5748, eISSN: 1873-474X) Title: International journal of developmental neuroscience : the official journal of the International Society for Developmental NeuroscienceTitle(ISO): Int J Dev NeurosciSupplier: International Society for Development NeurosciencePublisher: Wiley (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 52
| [継承] |
| ○号 (必須): |
| ○頁 (必須): | □ | 33 37
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 5月 12日 (平成 28年 5月 12日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.ijdevneu.2016.05.003 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 27181029 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○Scopus (任意): |
| ○機関リポジトリ : | □ | 112450
| [継承] |
| ○researchmap (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.ijdevneu.2016.05.003 (日)
| [継承] |
| 2. | (英) Article.ELocationID: S0736-5748(16)30049-1 (日)
| [継承] |
| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 4. | (英) KeywordList.Keyword: Hypothalamus (日)
| [継承] |
| 5. | (英) KeywordList.Keyword: Leptin (日)
| [継承] |
| 6. | (英) KeywordList.Keyword: PAC1 (日)
| [継承] |
| 7. | (英) KeywordList.Keyword: PACAP (日)
| [継承] |