| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Yamamoto Junpei (日) (読)
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| 2. | (英) Omura Midori (日) (読)
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| 3. | (英) Tuchiya Koichiro (日) (読)
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| 4. | (英) Hidaka Mayumi (日) (読)
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| 5. | 桑原 章
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| 6. | 苛原 稔
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| 7. | 田中 保 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系.食料科学分野])
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| 8. | 德村 彰
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| ○題名 (必須): | □ | (英) Preferable existence of polyunsaturated lysophosphatidic acids in human follicular fluid from patients programmed with in vitro fertilization. (日)
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| ○要約 (任意): | □ | (英) Lysophosphatidic acid (LPA) exerts diverse physiological effects on various types of animal cells, including reproductive cells, through its binding to six LPA receptors. We previously found that LPA promoted maturation of the nucleus and cytoplasm of mouse and hamster oocytes surrounded by cumulus cells in vitro. Using gas-liquid chromatography, we previously reported detection of several species of LPA by analyzing the fatty acid methyl esters derived from thin layer chromatography-purified LPA in lipid extract from incubated follicular fluids programmed with in vitro fertilization. In this study using liquid chromatography- tandem mass spectrometry, we directly detected high levels of linoleoyl, arachidonoyl, and docosahexaenoyl LPAs in human follicular fluid. This unique molecular species composition of LPA was suggested to be due to a balance between the low LPA-degrading activity and high LPA-producing activity of autotaxin in human follicular fluid. Our results suggest that polyunsaturated LPAs produced by autotaxin in human follicular fluid exert unknown physiological effects on cumulus cells. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Prostaglandins & Other Lipid Mediators ([Elsevier])
(pISSN: 1098-8823)
| ○ISSN (任意): | □ | 1098-8823
ISSN: 1098-8823
(pISSN: 1098-8823) Title: Prostaglandins & other lipid mediatorsTitle(ISO): Prostaglandins Other Lipid MediatPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 126
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 16 23
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 7月 12日 (平成 28年 7月 12日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.prostaglandins.2016.07.008 (→Scopusで検索)
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| ○PMID (任意): | □ | 27421691 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-84978805217
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| ○備考 (任意): | 1. | (英) Article.ELocationID: S1098-8823(16)30056-9 (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.prostaglandins.2016.07.008 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Liquid chromatography-tandem mass spectrometry (日)
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| 5. | (英) KeywordList.Keyword: Lysophosphatidylcholine (日)
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| 6. | (英) KeywordList.Keyword: Lysophospholipase D (日)
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| 7. | (英) KeywordList.Keyword: Ovary (日)
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