| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | 守田 剛 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔顎顔面形態学])
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| 2. | (英) Fujikawa Kaoru (日) (読)
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| 3. | 馬場 麻人 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔顎顔面形態学])
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| 4. | (英) Shunichi Shibata (日) (読)
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| ○題名 (必須): | □ | (英) An in situ hybridization study of Hyaluronan synthase (Has) mRNA in developing mouse molar and incisor tooth germs (日)
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| ○要約 (任意): | □ | (英) Hyaluronan (HA) is a major constituent molecule in most extracellular matrices and is synthesized by Hyaluronan synthase (Has). In the present study, we examined expression patterns of Has1, -2, -3 mRNA in developing mouse molar and incisor tooth germs from embryonic day (E) 11.5 to postnatal day (P) 7, focusing on Hertwig's epithelial root sheath (HERS) and the apical bud in particular. Has1 mRNA expression was not detected in all tooth germs examined. Has2 mRNA was expressed in the surrounding mesenchyme from E12.0 to 18.0 in both molar and incisor tooth germs, but disappeared after birth. Meanwhile, Has3 mRNA was exclusively expressed within the enamel organ, especially in the inner enamel epithelium (IEE), stellate reticulum (SR), and stratum intermedium (SI) until the early bell stage at E16.0. Has3 mRNA disappeared as IEE differentiated into differentiating ameloblasts (dABs), but remained in SI until the root developmental stage of the molar tooth germ at P7. Has3 mRNA was also expressed in HERS until P7. In incisors, Has3 mRNA was expressed in the apical bud, especially in the transit-amplifying (TA) cell region from E16.0 to P7, and in the papillary layer (PL) adjacent to the mature enamel. These gene expression patterns suggested that Has3 is the main control factor for prenatal and postnatal HA synthesis of the tooth germ, and may in part regulate crown and root formation of the tooth germ, maintenance of stem cell niches in the apical bud as well as mineral transport in PL. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Embryonic Development (日) (読)
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| 3. | (英) Enamel Organ (日) (読)
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| 4. | (英) Gene Expression Regulation, Developmental (日) (読)
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| 5. | (英) Glucuronosyltransferase (日) (読)
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| 6. | (英) Hyaluronic Acid (日) (読)
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| 7. | (英) In Situ Hybridization (日) (読)
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| 8. | (英) Incisor (日) (読)
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| 9. | (英) Mesoderm (日) (読)
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| 10. | (英) Mice (日) (読)
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| 11. | (英) Molar (日) (読)
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| 12. | (英) Odontogenesis (日) (読)
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| 13. | (英) RNA, Messenger (日) (読)
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| 14. | (英) Tooth Germ (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Gene Expression Patterns (International Society of Developmental Biologists)
(pISSN: 1567-133X, eISSN: 1872-7298)
| ○ISSN (任意): | □ | 1872-7298
ISSN: 1567-133X
(pISSN: 1567-133X, eISSN: 1872-7298) Title: Gene expression patterns : GEPTitle(ISO): Gene Expr PatternsPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 21
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 28 40
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 6月 8日 (平成 28年 6月 8日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.gep.2016.06.002 (→Scopusで検索)
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| ○PMID (任意): | □ | 27289075 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.gep.2016.06.002 (日)
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| 2. | (英) Article.ELocationID: S1567-133X(16)30058-8 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Hyaluronan (日)
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| 5. | (英) KeywordList.Keyword: Hyaluronan synthase (日)
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| 6. | (英) KeywordList.Keyword: In situ hybridization (日)
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| 7. | (英) KeywordList.Keyword: Mice (日)
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| 8. | (英) KeywordList.Keyword: Tooth germ (日)
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