| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | 桑野 由紀 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.遺伝情報医学])
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| 2. | 西田 憲生 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.医療教育学])
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| 3. | (英) Akaike Yoko (日) (読)
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| 4. | (英) Kurokawa Ken (日) (読)
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| 5. | 西川 達哉
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| 6. | 増田 清士
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| 7. | 六反 一仁
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| ○題名 (必須): | □ | (英) Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome. (日)
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| ○要約 (任意): | □ | (英) Homeodomain-interacting protein kinase 2 (HIPK2) is a serine/threonine kinase that phosphorylates and activates the apoptotic program through interaction with diverse downstream targets including tumor suppressor p53. HIPK2 is activated by genotoxic stimuli and modulates cell fate following DNA damage. The DNA damage response (DDR) is triggered by DNA lesions or chromatin alterations. The DDR regulates DNA repair, cell cycle checkpoint activation, and apoptosis to restore genome integrity and cellular homeostasis. Maintenance of the DDR is essential to prevent development of diseases caused by genomic instability, including cancer, defects of development, and neurodegenerative disorders. Recent studies reveal a novel HIPK2-mediated pathway for DDR through interaction with chromatin remodeling factor homeodomain protein 1. In this review, we will highlight the molecular mechanisms of HIPK2 and show its functions as a crucial DDR regulator. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | International Journal of Molecular Sciences (Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(pISSN: 1661-6596, eISSN: 1422-0067)
| ○ISSN (任意): | □ | 1422-0067
ISSN: 1661-6596
(pISSN: 1661-6596, eISSN: 1422-0067) Title: International journal of molecular sciencesTitle(ISO): Int J Mol SciPublisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 17
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| ○号 (必須): | □ | 10
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| ○頁 (必須): | □ |
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| ○年月日 (必須): | □ | 西暦 2016年 9月 27日 (平成 28年 9月 27日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/ijms17101638 (→Scopusで検索)
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| ○PMID (任意): | □ | 27689990 (→Scopusで検索)
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| ○Scopus (任意): | □ | 2-s2.0-84989282554
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| ○機関リポジトリ : | □ | 112409
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| ○備考 (任意): | 1. | (英) PublicationType: Review (日)
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| 2. | (英) PublicationType: Journal Article (日)
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