『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=326856)

EID=326856EID:326856, Map:0, LastModified:2018年8月21日(火) 20:35:57, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[長谷川 智一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ma Nan (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Yang Di (日) (読)
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学籍番号 (推奨):
[継承]
3.岡村 裕彦
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4.寺町 順平
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5.長谷川 智一 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.小児歯科学]/[徳島大学.病院.診療科.小児歯科])
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学籍番号 (推奨):
[継承]
6. (英) Qiu Lihong (日) (読)
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[継承]
7.羽地 達次
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[継承]
題名 (必須): (英) Involvement of interleukin23 induced by Porphyromonas endodontalis lipopolysaccharide in osteoclastogenesis  (日)    [継承]
副題 (任意):
要約 (任意): (英) Periapical lesions are characterized by the destruction of periapical bone, and occur as a result of local inflammatory responses to root canal infection by microorganisms including Porphyromonas endodontalis (P. endodontalis). P. endodontalis and its primary virulence factor, lipopolysaccharide (LPS), are associated with the development of periapical lesions and alveolar bone loss. Interleukin-23 (IL-23) is critical in the initiation and progression of periodontal disease via effects on peripheral bone metabolism. The present study investigated the expression of IL-23 in tissue where a periapical lesion was present, and the effect of P. endodontalis LPS on the expression of IL-23 in periodontal ligament (PDL) cells. Reverse transcription- quantitative polymerase chain reaction and immunohistochemistry revealed increased levels of IL-23 expression in tissue with periapical lesions compared with healthy PDL tissue. Treatment with P. endodontalis LPS increased the expression of IL-23 in the SH-9 human PDL cell line. BAY11-7082, a nuclear factor κB inhibitor, suppressed P. endodontalis LPS-induced IL-23 expression in SH-9 cells. Treatment of RAW264.7 cells with conditioned medium from P. endodontalis LPS-treated SH-9 cells promoted osteoclastogenesis. By contrast, RAW264.7 cells treated with conditioned medium from IL-23-knockdown SH-9 cells underwent reduced levels of osteoclastogenesis. The results of the present study indicated that the expression of IL-23 in PDL cells induced by P. endodontalis LPS treatment may be involved in the progression of periapical lesions via stimulation of the osteoclastogenesis process.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Chromones (日) (読) [継承]
3. (英) Humans (日) (読) [継承]
4. (英) Immunohistochemistry (日) (読) [継承]
5. (英) Interleukin-23 (日) (読) [継承]
6. (英) Lipopolysaccharides (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
8. (英) Morpholines (日) (読) [継承]
9. (英) NF-kappa B (日) (読) [継承]
10. (英) NFATC Transcription Factors (日) (読) [継承]
11. (英) Nitriles (日) (読) [継承]
12. (英) Osteoblasts (日) (読) [継承]
13. (英) Osteogenesis (日) (読) [継承]
14. (英) Periodontitis (日) (読) [継承]
15. (英) Phosphatidylinositol 3-Kinases (日) (読) [継承]
16. (英) Porphyromonas endodontalis (日) (読) [継承]
17. (英) Proto-Oncogene Proteins c-fos (日) (読) [継承]
18. (英) RANK Ligand (日) (読) [継承]
19. (英) RAW 264.7 Cells (日) (読) [継承]
20. (英) RNA Interference (日) (読) [継承]
21. (英) RNA, Small Interfering (日) (読) [継承]
22. (英) Sulfones (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Molecular Medicine Reports (Spandidos Publications)
(pISSN: 1791-2997, eISSN: 1791-3004)

ISSN (任意): 1791-3004
ISSN: 1791-2997 (pISSN: 1791-2997, eISSN: 1791-3004)
Title: Molecular medicine reports
Title(ISO): Mol Med Rep
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 559 566 [継承]
都市 (任意):
年月日 (必須): 西暦 2017年 2月 初日 (平成 29年 2月 初日) [継承]
URL (任意):
DOI (任意): 10.3892/mmr.2016.6041    (→Scopusで検索) [継承]
PMID (任意): 28000855    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.3892/mmr.2016.6041  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Nan Ma, Di Yang, Hirohiko Okamura, Jumpei Teramachi, Tomokazu Hasegawa, Lihong Qiu and Tatsuji Haneji : Involvement of interleukin23 induced by Porphyromonas endodontalis lipopolysaccharide in osteoclastogenesis, Molecular Medicine Reports, Vol.15, No.2, 559-566, 2017.
欧文冊子 ● Nan Ma, Di Yang, Hirohiko Okamura, Jumpei Teramachi, Tomokazu Hasegawa, Lihong Qiu and Tatsuji Haneji : Involvement of interleukin23 induced by Porphyromonas endodontalis lipopolysaccharide in osteoclastogenesis, Molecular Medicine Reports, Vol.15, No.2, 559-566, 2017.

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