| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Iwasa Takeshi (日) (読)
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| 2. | (英) Matsuzaki Toshiya (日) (読)
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| 3. | (英) Matsui Sumika (日) (読)
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| 4. | (英) Tungalagsuvd Altankhuu (日) (読)
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| 5. | (英) Munkhzaya Munkhsaikhan (日) (読)
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| 6. | (英) Takiguchi Eri (日) (読)
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| 7. | (英) Kawakita Takako (日) (読)
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| 8. | (英) Kuwahara Akira (日) (読)
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| 9. | 安井 敏之
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| 10. | (英) Irahara Minoru (日) (読)
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| ○題名 (必須): | □ | (英) The sensitivity of adipose tissue visfatin mRNA expression to lipopolysaccharide-induced endotoxemia is increased by ovariectomy in female rats. (日)
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| ○要約 (任意): | □ | (英) Visfatin plays an important role in inflammatory and metabolic conditions. In this study, the effects of septic stress on the serum, white-adipose-tissue (WAT), and liver visfatin levels of male and female rats were examined. Both gonadally intact (sham) and ovariectomized (OVX) female rats were used in order to evaluate the effects of the gonadal hormonal milieu on visfatin responses. Under the saline-injected conditions, the serum visfatin levels and the hepatic, subcutaneous, and visceral WAT visfatin mRNA levels of the OVX and sham rats did not differ. The serum visfatin levels and the subcutaneous, visceral WAT, and hepatic visfatin mRNA levels of both male and female rats were increased by the injection of a septic dose (5mg/kg) of LPS. At 6h after the injection of LPS, the WAT visfatin mRNA levels of the OVX rats were higher than those of the sham rats, whereas the serum visfatin levels and hepatic visfatin mRNA levels of the two groups did not differ. In the cultured visceral WAT, visfatin antagonist (FK-866) attenuated the LPS-induced up-regulations of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α). The pathophysiological roles of visfatin under septic conditions remain to be clarified. In addition, the precise mechanisms responsible for the increased WAT visfatin expression seen after ovariectomy and the effects of such changes should also be clarified. (日)
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| ○キーワード (推奨): | 1. | (英) Abdominal Fat (日) (読)
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| 2. | (英) Acrylamides (日) (読)
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| 3. | (英) Animals (日) (読)
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| 4. | (英) Cytokines (日) (読)
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| 5. | (英) Endotoxemia (日) (読)
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| 6. | (英) Female (日) (読)
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| 7. | (英) Gene Expression Regulation (日) (読)
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| 8. | (英) Gonadal Steroid Hormones (日) (読)
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| 9. | (英) Inflammation Mediators (日) (読)
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| 10. | (英) Lipopolysaccharides (日) (読)
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| 11. | (英) Liver (日) (読)
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| 12. | (英) Male (日) (読)
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| 13. | (英) Nicotinamide Phosphoribosyltransferase (日) (読)
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| 14. | (英) Ovariectomy (日) (読)
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| 15. | (英) Piperidines (日) (読)
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| 16. | (英) RNA, Messenger (日) (読)
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| 17. | (英) Rats (日) (読)
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| 18. | (英) Rats, Sprague-Dawley (日) (読)
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| 19. | (英) Subcutaneous Fat (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | International Immunopharmacology ([Elsevier])
(pISSN: 1567-5769, eISSN: 1878-1705)
| ○ISSN (任意): | □ | 1878-1705
ISSN: 1567-5769
(pISSN: 1567-5769, eISSN: 1878-1705) Title: International immunopharmacologyTitle(ISO): Int ImmunopharmacolPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 35
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| ○号 (必須): |
| ○頁 (必須): | □ | 243 247
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 4月 16日 (平成 28年 4月 16日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.intimp.2016.04.002 (→Scopusで検索)
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| ○PMID (任意): | □ | 27083000 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: S1567-5769(16)30136-9 (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.intimp.2016.04.002 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: LPS (日)
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| 5. | (英) KeywordList.Keyword: OVX (日)
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| 6. | (英) KeywordList.Keyword: Ovary (日)
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| 7. | (英) KeywordList.Keyword: Visfatin (日)
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