『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=326436)

EID=326436EID:326436, Map:0, LastModified:2017年7月27日(木) 13:29:34, Operator:[池本 哲也], Avail:TRUE, Censor:0, Owner:[池本 哲也], Read:継承, Write:継承, Delete:継承.
種別 (必須):
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Teraoku Hiroki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.森根 裕二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学]/[徳島大学.病院.診療科.外科.消化器・移植外科])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.池本 哲也 ([徳島大学.病院.中央診療施設等.安全管理部]/[徳島大学.病院.診療科.外科.消化器・移植外科])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.齋藤 裕 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.外科.消化器・移植外科])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Yamada Shinichiro (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Yoshikawa Masato (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.髙須 千絵 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8.東島 潤
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9.居村 暁
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
10.島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Role of thrombospondin-1 expression in colorectal liver metastasis and its molecular mechanism.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Thrombospondin-1 (THBS-1), a glycoprotein, is an endogenous inhibitor of angiogenesis and tumor growth. In this study, we investigated the clinical role and mechanism of THBS-1 expression in colorectal liver metastases, focusing on the relationships between its expression and tumor growth, epithelial-mesenchymal transition (EMT), and expression of other relevant molecules. Ninety-four patients who initially underwent curative hepatic resection were enrolled in this study and correlations between expression of THBS-1 (THBS-1 high [n = 35] and THBS-1 low [n = 59]) and tumor growth, Ki-67 labeling index (Ki-67 LI), expression of other relevant molecules, and microvessel density (MVD) investigated. THBS-1 low expression correlated with more advanced grade of liver and lymph node metastases and significantly worse overall survival than strong THBS-1 expression (3-year survival: 96.7% vs. 65.4%, P < 0.01). Multivariate analysis identified THBS-1 low expression as an independent prognostic factor (HR 2.82, 95% CI 1.21-7.71, P = 0.01). THBS-1 low expression correlated positively with high Ki-67 LI (P < 0.05) and inversely with E-cadherin (P < 0.05) and hypoxia inducible factor-1 (HIF-1 ) expression (P < 0.05); THBS-1 expression and MVD were not significantly correlated. Low THBS-1 expression may be an independent poor prognostic factor that affects tumor growth and EMT acquisition. Additionally, THBS-1 may be regulated by the HIF-1 pathway.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): Journal of Hepato-Biliary-Pancreatic Sciences (日本肝胆膵外科学会/Asian-Pacific Hepato-Pancreato-Biliary Association)
(pISSN: 1868-6974, eISSN: 1868-6982)

ISSN (任意): 1868-6982
ISSN: 1868-6974 (pISSN: 1868-6974, eISSN: 1868-6982)
Title: Journal of hepato-biliary-pancreatic sciences
Title(ISO): J Hepatobiliary Pancreat Sci
Supplier: Japanese Society of Hepato-Biliary-Pancreatic Surgery
Publisher: Springer Japan
 (NLM Catalog  (医中誌Web  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 23 [継承]
(必須): 9 [継承]
(必須): 565 573 [継承]
都市 (任意):
年月日 (必須): 西暦 2016年 8月 21日 (平成 28年 8月 21日) [継承]
URL (任意):
DOI (任意): 10.1002/jhbp.376    (→Scopusで検索) [継承]
PMID (任意): 27404020    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.1002/jhbp.376  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: Colorectal liver metastasis  (日)    [継承]
4.(英) KeywordList.Keyword: Immunohistochemistry  (日)    [継承]
5.(英) KeywordList.Keyword: Thrombospondin-1  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shinichiro Yamada, Masato Yoshikawa, Chie Takasu, Jun Higashijima, Satoru Imura and Mitsuo Shimada : Role of thrombospondin-1 expression in colorectal liver metastasis and its molecular mechanism., Journal of Hepato-Biliary-Pancreatic Sciences, Vol.23, No.9, 565-573, (発行所), (都市), Aug. 2016.
欧文冊子 ● (種別) : Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shinichiro Yamada, Masato Yoshikawa, Chie Takasu, Jun Higashijima, Satoru Imura and Mitsuo Shimada : Role of thrombospondin-1 expression in colorectal liver metastasis and its molecular mechanism., Journal of Hepato-Biliary-Pancreatic Sciences, Vol.23, No.9, 565-573, (発行所), (都市), Aug. 2016.

関連情報

Number of session users = 0, LA = 0.65, Max(EID) = 382135, Max(EOID) = 1020779.