| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Higashibata Takahiro (日) (読)
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| 2. | (英) Wakai Kenji (日) (読)
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| 3. | (英) Naito Mariko (日) (読)
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| 4. | (英) Morita Emi (日) (読)
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| 5. | (英) Hishida Asahi (日) (読)
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| 6. | (英) Hamajima Nobuyuki (日) (読)
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| 7. | (英) Hara Megumi (日) (読)
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| 8. | (英) Suzuki Sadao (日) (読)
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| 9. | (英) Hosono Satoyo (日) (読)
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| 10. | (英) Takashima Naoyuki (日) (読)
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| 11. | (英) Ohnaka Keizo (日) (読)
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| 12. | (英) Takada Akihiko (日) (読)
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| 13. | (英) Mikami Haruo (日) (読)
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| 14. | (英) Watanabe Yoshiyuki (日) (読)
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| 15. | 上村 浩一
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| 16. | (英) Kubo Michiaki (日) (読)
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| 17. | (英) Tanaka Hideo (日) (読)
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| ○題名 (必須): | □ | (英) Effects of self-reported calorie restriction on correlations between SIRT1 polymorphisms and body mass index and long-term weight change. (日)
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| ○要約 (任意): | □ | (英) SIRT1 acts as a cellular sensor to detect energy availability and modulates fat and glucose metabolism. This study assessed the effects of self-reported calorie restriction (CR) and exercise on correlations between SIRT1 polymorphisms and body mass index (BMI) and long-term weight change. This cross-sectional study enrolled 4023 subjects aged 35-69years (1847 men and 2176 women) selected from participants in the Japan Multi-Institutional Collaborative Cohort Study. This study was based on a self-administered questionnaire. No significant correlations between SIRT1 polymorphisms and BMI or long-term weight change were found in either the CR or the active groups. In the no-CR group, women with the rs1467568 G allele had a higher BMI than women without (p=0.02). Moreover, women with the rs7895833 A or rs1467568 G allele gained more weight from the age of 20years than women without these alleles (p=0.03 for rs7895833 and p=0.003 for rs1467568). In addition, the odds ratios (95% confidence intervals) of these alleles for overweight (BMI >27.5kg/m(2)) were significantly high in the no-CR women group (1.78 (1.06-2.99) for rs7895833 and 1.88 (1.13-3.15) for rs1467568) but not in the CR group. The results of this study suggest that CR might override the genetic contributions of the SIRT1 rs7895833 A and rs1467568 G alleles to BMI and long-term weight change. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Alleles (日) (読)
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| 3. | (英) Body Mass Index (日) (読)
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| 4. | (英) Caloric Restriction (日) (読)
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| 5. | (英) Cross-Sectional Studies (日) (読)
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| 6. | (英) Female (日) (読)
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| 7. | (英) Humans (日) (読)
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| 8. | (英) Male (日) (読)
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| 9. | (英) Overweight (日) (読)
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| 10. | (英) Polymorphism, Genetic (日) (読)
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| 11. | (英) Self Report (日) (読)
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| 12. | (英) Sirtuin 1 (日) (読)
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| 13. | (英) Time Factors (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Gene ([Elsevier Science B.V.])
(pISSN: 0378-1119, eISSN: 1879-0038)
| ○ISSN (任意): | □ | 1879-0038
ISSN: 0378-1119
(pISSN: 0378-1119, eISSN: 1879-0038) Title: GeneTitle(ISO): GenePublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 594
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 16 22
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 8月 31日 (平成 28年 8月 31日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.gene.2016.08.051 (→Scopusで検索)
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| ○PMID (任意): | □ | 27591970 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: S0378-1119(16)30697-7 (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.gene.2016.08.051 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Clinical Trial (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 5. | (英) KeywordList.Keyword: Cross-sectional study (日)
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| 6. | (英) KeywordList.Keyword: Gene-environment interaction (日)
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| 7. | (英) KeywordList.Keyword: Overweight (日)
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| 8. | (英) KeywordList.Keyword: SIRT1 (日)
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