| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | 松井 寿美佳
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| 2. | 安井 敏之
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| 3. | (英) Kasai Kana (日) (読)
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| 4. | (英) Keyama Kaoru (日) (読)
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| 5. | 加藤 剛志
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| 6. | 上村 浩一
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| 7. | 桑原 章
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| 8. | 松崎 利也
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| 9. | 苛原 稔
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| ○題名 (必須): | □ | (英) Changes of liver enzymes and triglyceride during the menopausal transition in Japanese women. (日)
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| ○要約 (任意): | □ | (英) We examined detailed changes in liver enzymes as surrogate markers for metabolic syndrome and non-alcoholic fatty liver disease (NAFLD) during the menopausal transition and the associations of liver enzymes with lipid profiles related to risk of metabolic syndrome and endocrinological hormones. We divided 393 women into seven stages by menstrual regularity, follicle-stimulating hormone level and years since menopause. Serum levels of alanine aminotranferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase, lipid parameters, glucose, and endocrinological hormones were measured. Both levels of AST and ALT increased towards early post-menopause. AST remained high in late post-menopause but ALT decreased. The AST/ALT ratio decreased towards late menopausal transition and very early post-menopause and increased thereafter. This ratio was negatively correlated with triglyceride. Significant changes in ALT and AST/ALT ratio during the menopausal transition, which were associated with triglyceride, might be involved in the occurrence of metabolic syndrome and NAFLD in Japanese women. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Age Factors (日) (読)
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| 3. | (英) Alanine Transaminase (日) (読)
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| 4. | (英) Aspartate Aminotransferases (日) (読)
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| 5. | (英) Blood Glucose (日) (読)
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| 6. | (英) Female (日) (読)
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| 7. | (英) Follicle Stimulating Hormone (日) (読)
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| 8. | (英) Humans (日) (読)
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| 9. | (英) Japan (日) (読)
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| 10. | (英) Lipids (日) (読)
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| 11. | (英) Liver (日) (読)
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| 12. | (英) Menopause (日) (読)
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| 13. | (英) Metabolic Syndrome X (日) (読)
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| 14. | (英) Middle Aged (日) (読)
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| 15. | (英) Non-alcoholic Fatty Liver Disease (日) (読)
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| 16. | (英) Risk Factors (日) (読)
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| 17. | (英) Time Factors (日) (読)
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| 18. | (英) Triglycerides (日) (読)
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| 19. | (英) gamma-Glutamyltransferase (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Obstetrics and Gynaecology (University of London. Institute of Obstetrics and Gynaecology)
(pISSN: 0144-3615, eISSN: 1364-6893)
| ○ISSN (任意): | □ | 1364-6893
ISSN: 0144-3615
(pISSN: 0144-3615, eISSN: 1364-6893) Title: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and GynaecologyTitle(ISO): J Obstet GynaecolPublisher: Taylor & Francis (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 36
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 806 811
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 5月 11日 (平成 28年 5月 11日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3109/01443615.2016.1154516 (→Scopusで検索)
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| ○PMID (任意): | □ | 27167882 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) KeywordList.Keyword: Liver enzymes (日)
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| 3. | (英) KeywordList.Keyword: lipids (日)
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| 4. | (英) KeywordList.Keyword: menopausal transition (日)
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