『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=325543)

EID=325543EID:325543, Map:0, LastModified:2018年5月23日(水) 17:06:45, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[北川 哲也], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.菅野 幹雄 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.心臓血管外科学]/[徳島大学.病院.診療科.外科.心臓血管外科])
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2. (英) Yoshida Homare (日) (読)
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3.黒部 裕嗣
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4.荒瀬 裕己
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5.木下 肇
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6.北市 隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.心臓血管外科学])
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7. (英) Sugasawa Noriko (日) (読)
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8. (英) Nakayama Soichiro (日) (読)
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9. (英) Maeda Kazuhisa (日) (読)
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10.苛原 稔 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
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11.北川 哲也
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題名 (必須): (英) Effects of Transplanted Human Cord Blood- Mononuclear Cells on Pulmonary Hypertension in Immunodeficient Mice and Their Distribution.  (日)    [継承]
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要約 (任意): (英) To investigate the effects of human umbilical cord blood-derived mononuclear cell (hUCB-MNC) transplantation on pulmonary hypertension (PH) induced by monocrotaline (MCT) in immunodeficient mice and their distribution. MCT was administered to BALB/c Slc-nu/nu mice, and PH was induced in mice 4 weeks later. Fresh hUCB-MNCs harvested from a human donor after her delivery were injected intravenously into those PH mice. The medial thickness of pulmonary arterioles, ratio of right ventricular to septum plus left ventricular weight (RV/S+LV), and ratio of acceleration time to ejection time of pulmonary blood flow waveform (AT/ET) were determined 4 weeks after hUCB-MNC transplantation. To reveal the incorporation into the lung, CMTMR-labeled hUCB-MNCs were observed in the lung by fluorescent microscopy. DiR-labeled hUCB-MNCs were detected in the lung and other organs by bioluminescence images. Medial thickness, RV/S+LV and AT/ET were significantly improved 4 weeks after hUCB-MNC transplantation compared with those in mice without hUCB-MNC transplantation. CMTMR-positive hUCB-MNCs were observed in the lung 3 hours after transplantation. Bioluminescence signals were detected more strongly in the lung than in other organs for 24 hours after transplantation. The results indicate that hUCB-MNCs are incorporated into the lung early after hUCB-MNC transplantation and improve MCT-induced PH. J. Med. Invest. 64: 43-49, February, 2017.  (日)    [継承]
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誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 64 [継承]
(必須): 1,2 [継承]
(必須): 43 49 [継承]
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年月日 (必須): 西暦 2017年 2月 1日 (平成 29年 2月 1日) [継承]
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DOI (任意): 10.2152/jmi.64.43    (→Scopusで検索) [継承]
PMID (任意): 28373627    (→Scopusで検索) [継承]
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機関リポジトリ : 111080 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.2152/jmi.64.43  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Mikio Sugano, Homare Yoshida, Hirotsugu Kurobe, Hiroki Arase, Hajime Kinoshita, Takashi Kitaichi, Noriko Sugasawa, Soichiro Nakayama, Kazuhisa Maeda, Minoru Irahara and Tetsuya Kitagawa : Effects of Transplanted Human Cord Blood- Mononuclear Cells on Pulmonary Hypertension in Immunodeficient Mice and Their Distribution., The Journal of Medical Investigation : JMI, Vol.64, No.1,2, 43-49, 2017.
欧文冊子 ● Mikio Sugano, Homare Yoshida, Hirotsugu Kurobe, Hiroki Arase, Hajime Kinoshita, Takashi Kitaichi, Noriko Sugasawa, Soichiro Nakayama, Kazuhisa Maeda, Minoru Irahara and Tetsuya Kitagawa : Effects of Transplanted Human Cord Blood- Mononuclear Cells on Pulmonary Hypertension in Immunodeficient Mice and Their Distribution., The Journal of Medical Investigation : JMI, Vol.64, No.1,2, 43-49, 2017.

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