| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | (英) Kondoh H (日) (読)
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| 2. | (英) Takada S (日) (読)
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| 3. | 竹本 龍也 ([徳島大学.先端酵素学研究所.基幹研究部門])
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| ○題名 (必須): | □ | (英) Axial level-dependent molecular and cellular mechanisms underlying the genesis of the embryonic neural plate. (日)
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| ○要約 (任意): | □ | (英) The transcription factor gene Sox2, centrally involved in neural primordial regulation, is activated by many enhancers. During the early stages of embryonic development, Sox2 is regulated by the enhancers N2 and N1 in the anterior neural plate (ANP) and posterior neural plate (PNP), respectively. This differential use of the enhancers reflects distinct regulatory mechanisms underlying the genesis of ANP and PNP. The ANP develops directly from the epiblast, triggered by nodal signal inhibition, and via the combined action of TFs SOX2, OTX2, POU3F1, and ZIC2, which promotes the the ANP development and inhibits other cell lineages. In contrast, the PNP is derived from neuromesodermal bipotential axial stem cells that develop into the neural plate when Sox2 is activated by the N1 enhancer, whereas they develop into the paraxial mesoderm when the N1 enhancer is repressed by the action of TBX6. The axial stem cells are maintained by the activity of WNT3a and T (Brachyury). However, at axial levels more anterior to the 8th somites (cervical levels), the development of both the neural plate and somite proceeds in the absence of WNT3a, T, or TBX6. These observations indicate that distinct molecular and cellular mechanisms determine neural plate genesis based on the axial level, and contradict the classical concept of the term "neural induction," which assumes a pan-neural plate mechanism. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Embryo, Mammalian (日) (読)
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| 3. | (英) Enhancer Elements, Genetic (日) (読)
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| 4. | (英) Gene Expression Regulation, Developmental (日) (読)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Neural Plate (日) (読)
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| 7. | (英) Transcription Factors (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Development Growth & Differentiation ([日本発生生物学会])
(pISSN: 0012-1592, eISSN: 1440-169X)
| ○ISSN (任意): | □ | 1440-169X
ISSN: 0012-1592
(pISSN: 0012-1592, eISSN: 1440-169X) Title: Development, growth & differentiationTitle(ISO): Dev Growth DifferSupplier: Japanese Society of Developmental BiologistsPublisher: Wiley Publishing (NLM Catalog)
(医中誌Web)
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| ○巻 (必須): | □ | 58
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 427 436
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 6月 9日 (平成 28年 6月 9日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/dgd.12295 (→Scopusで検索)
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| ○PMID (任意): | □ | 27279156 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1111/dgd.12295 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Review (日)
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| 4. | (英) KeywordList.Keyword: Sox2 enhancers (日)
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| 5. | (英) KeywordList.Keyword: Wnt signal (日)
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| 6. | (英) KeywordList.Keyword: axial stem cells (日)
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