| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Uno Yasuhiro (日) (読)
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| 2. | (英) Takata Ryo (日) (読)
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| 3. | (英) Kito Go (日) (読)
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| 4. | (英) Yamazaki Hiroshi (日) (読)
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| 5. | (英) Nakagawa Kazuko (日) (読)
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| 6. | (英) Nakamura Yusuke (日) (読)
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| 7. | (英) Kamataki Tetsuya (日) (読)
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| 8. | 片桐 豊雅
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| ○題名 (必須): | □ | (英) Sex- and age-dependent gene expression in human liver: An implication for drug-metabolizing enzymes. (日)
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| ○要約 (任意): | □ | (英) Sex and age differences in hepatic expression of drug-metabolizing enzyme genes could cause variations in drug metabolism, but has not been fully elucidated, especially in Asian population. In this study, the global expression of human hepatic genes was analyzed by microarrays in 40 Japanese subjects (27 males and 13 females). Thirty-five sex-biased genes were identified (P < 0.005). Whereas, 60 age-biased genes in two age groups, <60 years and ≥70 years (P < 0.001), were identified in males. By Gene Ontology analysis, the sex-biased genes were related to protein catabolism and modification, while the age-biased genes were related to transcription regulation and cell death. Quantitative polymerase chain reaction confirmed the female-biased expression of drug-metabolizing enzyme genes BChE, CYP4X1, and SULT1E1 (≥1.5-fold, P < 0.05). Further analysis of drug-metabolizing enzyme genes indicated that expression of CYP2A6 and CYP3A4 in females in the ≥70 age group was less than in the <60 age group (≥1.5-fold, P < 0.05), and this trend was also observed for PXR expression in males (≥1.5-fold, P < 0.05). The results presented provide important insights into hepatic physiology and function, especially drug metabolism, with respect to sex and age. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Drug Metabolism and Pharmacokinetics (日本薬物動態学会)
(pISSN: 1347-4367, eISSN: 1880-0920)
| ○ISSN (任意): | □ | 1880-0920
ISSN: 1347-4367
(pISSN: 1347-4367, eISSN: 1880-0920) Title: Drug metabolism and pharmacokineticsTitle(ISO): Drug Metab PharmacokinetSupplier: 日本薬物動態学会Publisher: Japanese Society for the Study of Xenobiotics (NLM Catalog)
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| ○巻 (必須): | □ | 32
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 100 107
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| ○年月日 (必須): | □ | 西暦 2016年 10月 27日 (平成 28年 10月 27日)
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| ○DOI (任意): | □ | 10.1016/j.dmpk.2016.10.409 (→Scopusで検索)
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| ○PMID (任意): | □ | 28153492 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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