EDB [Akiyama Nobuko/Takizawa Nobukazu/Miyauchi Maki/Yanai Hiromi/Tateishi Ryosuke/Shinzawa Miho/Yoshinaga Riko/Kurihara Masaaki/Demise Yosuke/Yasuda Hisataka/Yagi Shintaro/Wu Guoying/[松本満]/Sakamoto Reiko/Yoshida Nobuaki/Penninger M. Josef/Kobayashi Yasuhiro/Inoue Jun-ichiro/Akiyama Taishin/Identi cation of embryonic precursor cells that di erentiate into thymic epithelial cells expressing autoimmune regulator/[The Journal of Experimental Medicine]] (323737)

EID=323737

EID:323737, Map:0, LastModified:2018年11月29日(木) 11:56:46, Operator:[[ADMIN]], Avail:TRUE, Censor:承認済, Owner:[松本満], Read:継承, Write:継承, Delete:継承.

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学術論文 (審査論文)

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○言語 (必須):

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英語

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(英) Akiyama Nobuko (日) (読)

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(英) Takizawa Nobukazu (日) (読)

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(英) Miyauchi Maki (日) (読)

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(英) Yanai Hiromi (日) (読)

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(英) Tateishi Ryosuke (日) (読)

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(英) Shinzawa Miho (日) (読)

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(英) Yoshinaga Riko (日) (読)

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(英) Kurihara Masaaki (日) (読)

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(英) Demise Yosuke (日) (読)

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(英) Yasuda Hisataka (日) (読)

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(英) Yagi Shintaro (日) (読)

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(英) Wu Guoying (日) (読)

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松本満

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(英) Sakamoto Reiko (日) (読)

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(英) Yoshida Nobuaki (日) (読)

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(英) Penninger M. Josef (日) (読)

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(英) Kobayashi Yasuhiro (日) (読)

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(英) Inoue Jun-ichiro (日) (読)

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(英) Akiyama Taishin (日) (読)

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(英) Identi cation of embryonic precursor cells that di erentiate into thymic epithelial cells expressing autoimmune regulator (日)

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(英) Medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (Aire) are critical for preventing the onset of autoimmunity. However, the differentiation program of Aire-expressing mTECs (Aire+ mTECs) is unclear. Here, we describe novel embryonic precursors of Aire+ mTECs. We found the candidate precursors of Aire+ mTECs (pMECs) by monitoring the expression of receptor activator of nuclear factor-κB (RANK), which is required for Aire+ mTEC differentiation. pMECs unex- pectedly expressed cortical TEC molecules in addition to the mTEC markers UEA-1 ligand and RANK and differentiated into mTECs in reaggregation thymic organ culture. Introduction of pMECs in the embryonic thymus permitted long-term mainte- nance of Aire+ mTECs and ef ciently suppressed the onset of autoimmunity induced by Aire+ mTEC de ciency. Mechanistically, pMECs differentiated into Aire+ mTECs by tumor necrosis factor receptor-associated factor 6-dependent RANK signaling. Moreover, nonclassical nuclear factor-κB activation triggered by RANK and lymphotoxin-β receptor signaling promoted pMEC induction from progenitors exhibiting lower RANK expression and higher CD24 expression. Thus, our ndings identi ed two novel stages in the differentiation program of Aire+ mTECs. (日)

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○キーワード (推奨):

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The Journal of Experimental Medicine ([The Rockefeller University Press])

(pISSN: 0022-1007, eISSN: 1540-9538)

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1540-9538

ISSN: 0022-1007 (pISSN: 0022-1007, eISSN: 1540-9538)
Title: The Journal of experimental medicine
Title(ISO): J Exp Med
Publisher: Rockefeller University Press
(NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

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213

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8

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1441 1458

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西暦 2016年 7月 11日 (平成 28年 7月 11日)

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10.1084/jem.20151780 (→Scopusで検索)

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112343

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(英) Article.ELocationID: 10.4049/jimmunol.1400389 (日)

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(英) Article.PublicationTypeList.PublicationType: Journal Article (日)

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和文冊子 ●

Nobuko Akiyama, Nobukazu Takizawa, Maki Miyauchi, Hiromi Yanai, Ryosuke Tateishi, Miho Shinzawa, Riko Yoshinaga, Masaaki Kurihara, Yosuke Demise, Hisataka Yasuda, Shintaro Yagi, Guoying Wu, Mitsuru Matsumoto, Reiko Sakamoto, Nobuaki Yoshida, Josef M. Penninger, Yasuhiro Kobayashi, Jun-ichiro Inoue and Taishin Akiyama : Identi cation of embryonic precursor cells that di erentiate into thymic epithelial cells expressing autoimmune regulator, The Journal of Experimental Medicine, 213, 8, 1441-1458, 2016.

欧文冊子 ●

Nobuko Akiyama, Nobukazu Takizawa, Maki Miyauchi, Hiromi Yanai, Ryosuke Tateishi, Miho Shinzawa, Riko Yoshinaga, Masaaki Kurihara, Yosuke Demise, Hisataka Yasuda, Shintaro Yagi, Guoying Wu, Mitsuru Matsumoto, Reiko Sakamoto, Nobuaki Yoshida, Josef M. Penninger, Yasuhiro Kobayashi, Jun-ichiro Inoue and Taishin Akiyama : Identi cation of embryonic precursor cells that di erentiate into thymic epithelial cells expressing autoimmune regulator, The Journal of Experimental Medicine, 213, 8, 1441-1458, 2016.

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