| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Murakami, M. (日) (読)
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| 2. | 山本 圭 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生命科学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命コース])
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| 3. | 三木 寿美 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.創薬理論化学]/[徳島大学.フォトニクス健康フロンティア研究院])
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| 4. | (英) Murase, R. (日) (読)
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| 5. | (英) Sato, H. (日) (読)
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| 6. | (英) Taketomi, Y. (日) (読)
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| ○題名 (必須): | □ | (英) The roles of the secreted phospholipase A2 gene family in immunology (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Within the phospholipase A2 (PLA2) family that hydrolyzes phospholipids to yield fatty acids and lysophospholipids, secreted PLA2 (sPLA2) enzymes comprise the largest group containing 11 isoforms in mammals. Individual sPLA2s exhibit unique tissue or cellular distributions and enzymatic properties, suggesting their distinct biological roles. Although PLA2 enzymes, particularly cytosolic PLA2 (cPLA2), have long been implicated in inflammation by driving arachidonic acid metabolism, the precise biological roles of sPLA2s have remained a mystery over the last few decades. Recent studies employing mice gene-manipulated for individual sPLA2s, in combination with mass spectrometric lipidomics to identify their target substrates and products in vivo, have revealed their roles in diverse biological events, including immunity and associated disorders, through lipid mediator-dependent or -independent processes in given microenvironments. In this review, we summarize our current knowledge of the roles of sPLA2s in various immune responses and associated diseases. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Advances in Immunology ([Elsevier])
(pISSN: 0065-2776, eISSN: 1557-8445)
| ○ISSN (任意): | □ | 1557-8445
ISSN: 0065-2776
(pISSN: 0065-2776, eISSN: 1557-8445) Title: Advances in immunologyTitle(ISO): Adv ImmunolPublisher: Academic Press Inc. (NLM Catalog)
(Scopus)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 132
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 91 134
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 5月 初日 (平成 28年 5月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/bs.ai.2016.05.001 (→Scopusで検索)
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| ○PMID (任意): | □ | 27769509 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-84999885111
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| ○備考 (任意): | 1. | (英) Article.ELocationID: S0065-2776(16)30034-7 (日)
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| 2. | (英) Article.ELocationID: 10.1016/bs.ai.2016.05.001 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Arachidonic acid (日)
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| 5. | (英) KeywordList.Keyword: Docosahexaenoic acid (日)
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| 6. | (英) KeywordList.Keyword: Eicosanoid (日)
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| 7. | (英) KeywordList.Keyword: Fatty acid (日)
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| 8. | (英) KeywordList.Keyword: Leukotriene (日)
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| 9. | (英) KeywordList.Keyword: Lysophospholipid (日)
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| 10. | (英) KeywordList.Keyword: Membrane (日)
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| 11. | (英) KeywordList.Keyword: Phospholipase A(2) (日)
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| 12. | (英) KeywordList.Keyword: Phospholipid (日)
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| 13. | (英) KeywordList.Keyword: Prostaglandin (日)
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