| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kozaki Tatsuya (日) (読)
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| 2. | (英) Komano Jun (日) (読)
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| 3. | (英) Kanbayashi Daiki (日) (読)
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| 4. | 髙濵 充寛
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| 5. | (英) Misawa Takuma (日) (読)
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| 6. | (英) Satoh Takashi (日) (読)
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| 7. | (英) Takeuchi Osamu (日) (読)
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| 8. | (英) Kawai Taro (日) (読)
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| 9. | (英) Shimizu Shigeomi (日) (読)
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| 10. | (英) Matsuura Yoshiharu (日) (読)
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| 11. | (英) Akira Shizuo (日) (読)
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| 12. | 齊藤 達哉
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| ○題名 (必須): | □ | (英) Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response. (日)
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| ○要約 (任意): | □ | (英) The innate immune system senses RNA viruses by pattern recognition receptors (PRRs) and protects the host from virus infection. PRRs mediate the production of immune modulatory factors and direct the elimination of RNA viruses. Here, we show a unique PRR that mediates antiviral response. Tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP ribose) polymerase (TIPARP), a Cysteine3 Histidine (CCCH)-type zinc finger-containing protein, binds to Sindbis virus (SINV) RNA via its zinc finger domain and recruits an exosome to induce viral RNA degradation. TIPARP typically localizes in the nucleus, but it accumulates in the cytoplasm after SINV infection, allowing targeting of cytoplasmic SINV RNA. Redistribution of TIPARP is induced by reactive oxygen species (ROS)-dependent oxidization of the nuclear pore that affects cytoplasmic-nuclear transport. BCL2-associated X protein (BAX) and BCL2 antagonist/killer 1 (BAK1), B-cell leukemia/lymphoma 2 (BCL2) family members, mediate mitochondrial damage to generate ROS after SINV infection. Thus, TIPARP is a viral RNA-sensing PRR that mediates antiviral responses triggered by BAX- and BAK1-dependent mitochondrial damage. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Proceedings of the National Academy of Sciences of the United States of America ([The National Academy of Sciences of the United States of America])
(pISSN: 0027-8424, eISSN: 1091-6490)
| ○ISSN (任意): | □ | 1091-6490
ISSN: 0027-8424
(pISSN: 0027-8424, eISSN: 1091-6490) Title: Proceedings of the National Academy of Sciences of the United States of AmericaTitle(ISO): Proc Natl Acad Sci U S APublisher: National Academy of Sciences (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 114
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| ○号 (必須): | □ | 10
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| ○頁 (必須): | □ | 2681 2686
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 2月 17日 (平成 29年 2月 17日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1073/pnas.1621508114 (→Scopusで検索)
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| ○PMID (任意): | □ | 28213497 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-85014711257
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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