| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Kawamoto Norio (日) (読)
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| 2. | 亀村 典生
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| 3. | 木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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| 4. | (英) Fukao Toshiyuki (日) (読)
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| ○題名 (必須): | □ | (英) Detection of ovomucoid-specific low-affinity IgE in infants and its relationship to eczema. (日)
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| ○要約 (任意): | □ | (英) Allergen-specific low-affinity IgE was previously detected in cord blood by a highly sensitive densely carboxylated protein (DCP) chip, but not by ImmunoCAP. Here, we investigated the presence of low-affinity IgE during the early life of infants and observed its relationship with eczema. We conducted a birth cohort study, collecting sera at birth and 6 (6M) and 14 months (14M) of age (n=110). We monitored the ovomucoid (OM)- and egg white (EW)-specific-IgE (sIgE) by ImmunoCAP or DCP-chip and analyzed the antigen-affinity of sIgE by binding inhibition assays in the presence or absence of a mild chaotropic agent, diethyl amine (DEA). The low- and high-affinity OM-sIgEs and sensitization risk factors were analyzed by a multivariate logistic analysis. The OM-sIgE measured by DCP-chip significantly correlated with that measured by ImmunoCAP, but some samples assessed as OM-sIgE-positive by DCP-chip were considered OM-sIgE-negative by ImmunoCAP. Binding inhibition analysis after DEA treatment was performed for participants judged as OM-sIgE-positive by DCP-chip at 14M. The group assessed as negative for OM- and EW-sIgE by ImmunoCAP at 6M and 14M showed a larger binding inhibition curve shift after DEA treatment than did the group assessed as positive at these times, indicating the presence of low-affinity sIgE antibodies at 14M. The logistic regression analysis found that persistent eczema from 6M to 14M is a significant risk factor for developing high-affinity, but not low-affinity, sIgE. Human infant peripheral blood contains allergen-specific low-affinity sIgE. Persistent eczema is related to the development of high-affinity, but not low-affinity, IgE. This article is protected by copyright. All rights reserved. (日)
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| ○キーワード (推奨): | 1. | (英) Allergens (日) (読)
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| 2. | (英) Antibody Affinity (日) (読)
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| 3. | (英) Cohort Studies (日) (読)
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| 4. | (英) Eczema (日) (読)
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| 5. | (英) Egg Hypersensitivity (日) (読)
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| 6. | (英) Female (日) (読)
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| 7. | (英) Humans (日) (読)
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| 8. | (英) Immunoglobulin E (日) (読)
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| 9. | 小児 (infant)
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| 10. | (英) Male (日) (読)
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| 11. | (英) Ovomucin (日) (読)
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| 12. | (英) Risk Factors (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Pediatric Allergy and Immunology (European Society of Pediatric Allergy and Immunology)
(pISSN: 0905-6157, eISSN: 1399-3038)
| ○ISSN (任意): | □ | 1399-3038
ISSN: 0905-6157
(pISSN: 0905-6157, eISSN: 1399-3038) Title: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and ImmunologyTitle(ISO): Pediatr Allergy ImmunolSupplier: European Academy of Allergy and Clinical ImmunologyPublisher: Blackwell (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 28
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 355 361
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 1月 31日 (平成 29年 1月 31日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/pai.12702 (→Scopusで検索)
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| ○PMID (任意): | □ | 28140473 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-85014568024
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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