| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Yoshida Ichiro (日) (読)
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| 2. | (英) Ito Chihiro (日) (読)
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| 3. | (英) Matsuda Shinya (日) (読)
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| 4. | 辻 明彦
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| 5. | (英) Yanaka Noriyuki (日) (読)
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| 6. | 湯浅 恵造
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| ○題名 (必須): | □ | (英) Alisol B, a triterpene from Alismatis rhizoma (dried rhizome of Alisma orientale), inhibits melanin production in murine B16 melanoma cells (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) To develop new whitening agents from natural products, we screened 80 compounds derived from crude drugs in Kampo medicine in a melanin synthesis inhibition assay using murine B16 melanoma cells. The screen revealed that treatment with alisol B, a triterpene from Alismatis rhizoma, significantly decreased both melanin content and cellular tyrosinase activity in B16 cells. However, alisol B did not directly inhibit mushroom tyrosinase activity in vitro. Therefore, we investigated the mechanism underlying the inhibitory effect of alisol B on melanogenesis. Alisol B suppressed mRNA induction of tyrosinase and its transcription factor, microphthalmia-associated transcription factor (MITF). Furthermore, alisol B reduced the phosphorylation of CREB and maintained the activation of ERK1/2. These results suggest that the reduction in melanin production by alisol B is due to the downregulation of MITF through the suppression of CREB and activation of ERK and that alisol B may be useful as a new whitening agent. (日)
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| ○キーワード (推奨): | 1. | (英) Alisma (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Cell Line, Tumor (日) (読)
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| 4. | (英) Cholestenones (日) (読)
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| 5. | (英) Cyclic AMP Response Element-Binding Protein (日) (読)
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| 6. | (英) Drug Evaluation, Preclinical (日) (読)
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| 7. | (英) Melanins (日) (読)
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| 8. | (英) Melanoma, Experimental (日) (読)
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| 9. | (英) Mice (日) (読)
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| 10. | (英) Microphthalmia-Associated Transcription Factor (日) (読)
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| 11. | (英) Monophenol Monooxygenase (日) (読)
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| 12. | リン酸化 (phosphorylation)
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| 13. | (英) Rhizome (日) (読)
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| 14. | シグナル伝達 (signal transduction)
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| 15. | (英) Skin Lightening Preparations (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Bioscience, Biotechnology, and Biochemistry ([社団法人 日本農芸化学会])
(pISSN: 0916-8451, eISSN: 1347-6947)
| ○ISSN (任意): | □ | 1347-6947
ISSN: 0916-8451
(pISSN: 0916-8451, eISSN: 1347-6947) Title: Bioscience, biotechnology, and biochemistryTitle(ISO): Biosci Biotechnol BiochemSupplier: 社団法人日本農芸化学会Publisher: Oxford University Press (NLM Catalog)
(CiNii NCID)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 81
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 534 540
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 1月 4日 (平成 29年 1月 4日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1080/09168451.2016.1268042 (→Scopusで検索)
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| ○PMID (任意): | □ | 28051915 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-85012247112
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| ○機関リポジトリ : | □ | 111886
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| ○researchmap (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1080/09168451.2016.1268042 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Kampo (日)
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| 4. | (英) KeywordList.Keyword: alisol B (日)
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| 5. | (英) KeywordList.Keyword: melanogenesis (日)
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| 6. | (英) KeywordList.Keyword: microphthalmia-associated transcription factor (MITF) (日)
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| 7. | (英) KeywordList.Keyword: tyrosinase (日)
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