| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Shikata Yuki (日) (読)
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| 2. | 吉丸 哲郎 ([徳島大学.先端酵素学研究所.重点研究部門])
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| 3. | 小松 正人
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| 4. | (英) Katoh Hiroto (日) (読)
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| 5. | (英) Sato Reiko (日) (読)
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| 6. | (英) Kanagaki Shuhei (日) (読)
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| 7. | (英) Okazaki Yasumasa (日) (読)
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| 8. | (英) Toyokuni Shinya (日) (読)
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| 9. | (英) Tashiro Etsu (日) (読)
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| 10. | (英) Ishikawa Shumpei (日) (読)
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| 11. | 片桐 豊雅
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| 12. | (英) Imoto Masaya (日) (読)
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| ○題名 (必須): | □ | (英) Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor. (日)
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| ○要約 (任意): | □ | (英) Xanthohumol (XN), a simple prenylated chalcone, can be isolated from hops and has the potential to be a cancer chemopreventive agent against several human tumor cell lines. We previously identified valosin-containing protein (VCP) as a target of XN; VCP can also play crucial roles in cancer progression and prognosis. Therefore, we investigated the molecular mechanisms governing the contribution of VCP to the antitumor activity of XN. Several human tumor cell lines were treated with XN to investigate which human tumor cell lines are sensitive to XN. Several cell lines exhibited high sensitivity to XN both in vitro and in vivo. shRNA screening and bioinformatics analysis identified that the inhibition of the adenylate cyclase (AC) pathway synergistically facilitated apoptosis induced by VCP inhibition. These results suggest there is crosstalk between the AC pathway and VCP function, and targeting both VCP and the AC pathway is a potential chemotherapeutic strategy for a subset of tumor cells. This article is protected by copyright. All rights reserved. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Cancer Science ([日本癌学会])
(pISSN: 1347-9032, eISSN: 1349-7006)
| ○ISSN (任意): | □ | 1349-7006
ISSN: 1347-9032
(pISSN: 1347-9032, eISSN: 1349-7006) Title: Cancer scienceTitle(ISO): Cancer SciPublisher: Wiley-Blackwell (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 108
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 785 794
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| ○年月日 (必須): | □ | 西暦 2017年 4月 20日 (平成 29年 4月 20日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/cas.13175 (→Scopusで検索)
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| ○PMID (任意): | □ | 28122154 (→Scopusで検索)
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| ○機関リポジトリ : | □ | 112374
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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