『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=322449EID:322449, Map:0, LastModified:2025年8月13日(水) 13:05:40, Operator:[[ADMIN]], Avail:TRUE, Censor:承認済, Owner:[山本 武範], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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著者 (必須): 1. (英) Yoshimura Yuya (日) (読)
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[継承]
2. (英) Fujisaki Kosuke (日) (読)
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[継承]
3.山本 武範
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4.篠原 康雄 ([徳島大学.先端酵素学研究所.基幹研究部門])
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[継承]
題名 (必須): (英) Pharmacokinetic Studies of Orally Administered Magnesium Oxide in Rats.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Magnesium oxide (MgO) tablets are widely used as laxatives in patients with constipation. Recently, the "Revision of Precautions on the Use of Magnesium Oxide" has been issued by the Japanese Pharmaceuticals and Medical Devices Agency, warning against the risk of hypermagnesemia with the use of MgO. However, the majority of physicians continue to administer MgO for constipation without adequately considering its safe use. In the present study, we performed two analyses using an identical lot of MgO tablets and evaluated the risk of hypermagnesemia. Approximately 90% of the MgO tablets dissolved within 120 min in dissolution testing; it was believed to form an absorbable state for magnesium. With orally administered MgO, 15% is absorbed in the body and 85% is excreted via the feces without being detected in pharmacokinetic analysis. Magnesium absorbed into the plasma demonstrated peak concentration 3 h after administration and was excreted via the urine within 48 h.  (日)    [継承]
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誌名 (必須): 薬学雑誌 ([日本薬学会])
(pISSN: 0031-6903, eISSN: 1347-5231)

ISSN (任意): 1347-5231
ISSN: 0031-6903 (pISSN: 0031-6903, eISSN: 1347-5231)
Title: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Title(ISO): Yakugaku Zasshi
Supplier: 公益社団法人日本薬学会
Publisher: Pharmaceutical Society of Japan
 (NLM Catalog  (CiNii NCID  (CiNii NCID  (医中誌Web  (J-STAGE  (J-STAGE  (J-STAGE  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2017年 1月 26日 (平成 29年 1月 26日) [継承]
URL (任意):
DOI (任意): 10.1248/yakushi.16-00020    (→Scopusで検索) [継承]
PMID (任意): 28123145    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yuya Yoshimura, Kosuke Fujisaki, Takenori Yamamoto and Yasuo Shinohara : Pharmacokinetic Studies of Orally Administered Magnesium Oxide in Rats., Journal of the Pharmaceutical Society of Japan, 2017.
欧文冊子 ● Yuya Yoshimura, Kosuke Fujisaki, Takenori Yamamoto and Yasuo Shinohara : Pharmacokinetic Studies of Orally Administered Magnesium Oxide in Rats., Journal of the Pharmaceutical Society of Japan, 2017.

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