| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 岡下 修己
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| 2. | (英) Suwa Yoshiaki (日) (読)
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| 3. | (英) Nishimura Osamu (日) (読)
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| 4. | (英) Sakashita Nao (日) (読)
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| 5. | (英) Kadota Mitsutaka (日) (読)
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| 6. | (英) Nagamatsu Go (日) (読)
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| 7. | (英) Kawaguchi Masanori (日) (読)
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| 8. | (英) Kashida Hiroki (日) (読)
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| 9. | (英) Nakajima Ayaka (日) (読)
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| 10. | 立花 誠
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| 11. | (英) Seki Yoshiyuki (日) (読)
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| ○題名 (必須): | □ | (英) PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency. (日)
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| ○要約 (任意): | □ | (英) Primordial germ cells (PGCs) are specified from epiblast cells in mice. Genes associated with naive pluripotency are repressed in the transition from inner cell mass to epiblast cells, followed by upregulation after PGC specification. However, the molecular mechanisms underlying the reactivation of pluripotency genes are poorly characterized. Here, we exploited the in vitro differentiation of epiblast-like cells (EpiLCs) from embryonic stem cells (ESCs) to elucidate the molecular and epigenetic functions of PR domain-containing 14 (PRDM14). We found that Prdm14 overexpression in EpiLCs induced their conversion to ESC-like cells even in the absence of leukemia inhibitory factor in adherent culture. This was impaired by the loss of Kruppel-like factor 2 and ten-eleven translocation (TET) proteins. Furthermore, PRDM14 recruited OCT3/4 to the enhancer regions of naive pluripotency genes via TET-base excision repair-mediated demethylation. Our results provide evidence that PRDM14 establishes a transcriptional network for naive pluripotency via active DNA demethylation. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Stem Cell Reports (International Society for Stem Cell Research)
(eISSN: 2213-6711)
| ○ISSN (任意): | □ | 2213-6711
ISSN: 2213-6711
(eISSN: 2213-6711) Title: Stem cell reportsTitle(ISO): Stem Cell ReportsPublisher: Cell Press (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 7
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 1072 1086
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| ○年月日 (必須): | □ | 西暦 2016年 11月 17日 (平成 28年 11月 17日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.stemcr.2016.10.007 (→Scopusで検索)
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| ○PMID (任意): | □ | 27866876 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-85004115535
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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