| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 徳島大学以外での単独著作 (徳島大学以外での単一の研究グループ(研究室等)内の研究 (単著も含む))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 廣島 佑香 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔微生物学])
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| 2. | (英) Hsu Kenneth (日) (読)
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| 3. | (英) Tedla Nicodemus (日) (読)
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| 4. | (英) Wong Wing Sze (日) (読)
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| 5. | (英) Chow Sharron (日) (読)
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| 6. | (英) Kawaguchi Naomi (日) (読)
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| 7. | (英) Geczy L Carolyn (日) (読)
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| ○題名 (必須): | □ | (英) S100A8/A9 and S100A9 reduce acute lung injury. (日)
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| ○要約 (任意): | □ | (英) S100A8 and S100A9 are myeloid cell-derived proteins that are elevated in several types of inflammatory lung disorders. Pro- and anti-inflammatory properties are reported and these proteins are proposed to activate TLR4. S100A8 and S100A9 can function separately, likely through distinct receptors but a systematic comparison of their effects in vivo are limited. Here we assess inflammation in murine lung following S100A9 and S100A8/A9 inhalation. Unlike S100A8, S100A9 promoted mild neutrophil and lymphocyte influx, possibly mediated in part, by increased mast cell degranulation and selective upregulation of some chemokine genes, particularly CXCL-10. S100 proteins did not significantly induce proinflammatory mediators including TNF-, IL-1, IL-6 or serum amyloid A3 (SAA3). In contrast to S100A8, neither preparation induced S100A8 or IL-10 mRNA/protein in airway epithelial cells, or in tracheal epithelial cells in vitro. Like S100A8, S100A9 and S100A8/A9 reduced neutrophil influx in acute lung injury (ALI) provoked by LPS challenge but were somewhat less inhibitory, possibly because of differential effects on expression of some chemokines, IL-1, SAA3 and IL-10. Novel common pathways including increased induction of an NAD(+)-dependent protein deacetylase sirtuin-1 (SIRT1) that may reduce NF-B signalling, and increased STAT3 activation may reduce LPS activation. Results suggest a role for these proteins in normal homeostasis and protective mechanisms in the lung.Immunology and Cell Biology accepted article preview online, 11 January 2017. doi:10.1038/icb.2017.2. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Immunology and Cell Biology (Australian Society for Immunology)
(pISSN: 0818-9641, eISSN: 1440-1711)
| ○ISSN (任意): | □ | 1440-1711
ISSN: 0818-9641
(pISSN: 0818-9641, eISSN: 1440-1711) Title: Immunology and cell biologyTitle(ISO): Immunol Cell BiolSupplier: Australian and New Zealand Society for ImmunologyPublisher: Wiley (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 95
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 461 472
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 1月 11日 (平成 29年 1月 11日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/icb.2017.2 (→Scopusで検索)
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| ○PMID (任意): | □ | 28074060 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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