| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Sato T (日) (読)
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| 2. | (英) Hayakawa K (日) (読)
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| 3. | (英) Noda M (日) (読)
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| 4. | (英) Kamikonya N (日) (読)
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| 5. | (英) Wanatabe T (日) (読)
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| 6. | (英) Kato D (日) (読)
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| 7. | (英) Sakai Y (日) (読)
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| 8. | (英) Hiraoka M (日) (読)
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| 9. | (英) Shimada M (日) (読)
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| 10. | 生島 仁史 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.放射線科学系.放射線治療学])
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| 11. | (英) Baba H (日) (読)
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| 12. | (英) Oya N (日) (読)
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| 13. | (英) Nemoto-Murofushi K (日) (読)
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| 14. | (英) Takeuchi M (日) (読)
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| 15. | (英) Watanabe M (日) (読)
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| ○題名 (必須): | □ | (英) A multicenter phase I study of preoperative chemoradiotherapy with S-1 and irinotecan for locally advanced lower rectal cancer (SAMRAI-1). (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Preoperative 5-fluorouracil-based chemoradiotherapy is a standard treatment for locally advanced lower rectal cancer (LALRC). We performed a phase I study to develop a new regimen combining irinotecan and S-1. Patients with LALRC (T3-4, N0-2) were studied. The radiation dose was 45Gy in 25 fractions. S-1 (80mg/m(2)/day) was administered on days 1-5, 8-12, 22-26, and 29-33. Irinotecan was administered on days 1, 8, 22, and 29. The dose of irinotecan was initially 60mg/m(2) (level 1). Surgery was performed 6-10weeks after the chemoradiotherapy. Twenty patients were enrolled, of whom 18 patients were analyzed. Dose-limiting toxicity (DLT) did not occur in the first 3 patients treated with irinotecan at 80mg/m(2) (level 2), but developed in 3 of the 6 patients who received irinotecan at 90mg/m(2) (level 3). Then DLT occurred in 3 other patients at level 2. At level 2 or 3, DLT comprised neutropenia, thrombocytopenia, and diarrhea. Level 2 was designated as the maximum tolerated dose, and level 1 as a recommended dose (RD). The pathological complete response rate was 28%, and the down-staging rate was 56%. Our results suggested that the RD of irinotecan when combined with preoperative S-1 and pelvic radiation was 60mg/m(2). (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Radiotherapy and Oncology (European Society for Therapeutic Radiology and Oncology)
(pISSN: 0167-8140, eISSN: 1879-0887)
| ○ISSN (任意): | □ | 1879-0887
ISSN: 0167-8140
(pISSN: 0167-8140, eISSN: 1879-0887) Title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and OncologyTitle(ISO): Radiother OncolPublisher: Elsevier Ireland Ltd (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 120
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 222 227
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 8月 初日 (平成 28年 8月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.radonc.2016.06.002 (→Scopusで検索)
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| ○PMID (任意): | □ | 27317556 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.radonc.2016.06.002 (日)
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| 2. | (英) Article.ELocationID: S0167-8140(16)31148-3 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) OtherID: PMC5013752 (日)
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| 5. | (英) KeywordList.Keyword: Irinotecan (日)
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| 6. | (英) KeywordList.Keyword: Neoadjuvant chemoradiotherapy (日)
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| 7. | (英) KeywordList.Keyword: Rectal cancer (日)
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| 8. | (英) KeywordList.Keyword: S-1 (日)
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