| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 森 博康
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| 2. | 黒田 暁生
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| 3. | (英) Araki Michiko (日) (読)
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| 4. | (英) Suzuki Reiko (日) (読)
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| 5. | 谷口 諭
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| 6. | 田蒔 基行
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| 7. | (英) Akehi Yuko (日) (読)
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| 8. | 松久 宗英
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| ○題名 (必須): | □ | (英) Advanced glycation end products is a risk for muscle weakness in Japanese patients with type 1 diabetes. (日)
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| ○要約 (任意): | □ | (英) Accumulation of advanced glycation end products (AGEs) is thought to contribute to muscle weakness in a diabetic animal model. Skin autofluorescence (AF) is a proposed marker for accumulation of AGEs in the skin. We aimed to investigate the relationship between AGEs accumulation, sarcopenia, and muscle function of Japanese patients with type 1 diabetes. Thirty-six patients with type 1 diabetes participated in this cross-sectional study. Sarcopenia parameters (skeletal muscle mass index (SMI) and knee extension strength) were compared with subcutaneous AGEs accumulation using skin AF. The prevalence of sarcopenia and impaired knee extension strength was 16.6% (male: 0.0%, female: 22.2%) and 47.2% (male: 22.2%, female: 55.6%), respectively. Knee extension strength was negatively correlated with skin AF (r²= 0.14, p < 0.05), but not with SMI. In conclusion, the AGEs accumulation might be one of the reasons of impaired lower limb muscle function in Japanese patients with type 1 diabetes. This article is protected by copyright. All rights reserved. (日)
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| ○発行所 (推奨): | □ | (英) 2017 May;8(3):377-382 (日) (読)
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| ○誌名 (必須): | □ | Journal of Diabetes Investigation (Asian Association for the Study of Diabetes)
(pISSN: 2040-1116, eISSN: 2040-1124)
| ○ISSN (任意): | □ | 2040-1124
ISSN: 2040-1116
(pISSN: 2040-1116, eISSN: 2040-1124) Title: Journal of diabetes investigationTitle(ISO): J Diabetes InvestigPublisher: John Wiley and Sons Inc (NLM Catalog)
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| ○巻 (必須): | □ | 8
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 377 382
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| ○年月日 (必須): | □ | 西暦 2017年 5月 末日 (平成 29年 5月 末日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/jdi.12582 (→Scopusで検索)
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| ○PMID (任意): | □ | 27727515 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: JOURNAL ARTICLE (日)
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