| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Oboshi Wataru (日) (読)
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| 2. | 安藝 健作 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.細胞・免疫解析学])
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| 3. | (英) Tada Tomoki (日) 多田 智紀 (読) ただ ともき
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 4. | (英) Watanabe Toru (日) (読)
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| 5. | (英) Yukimasa Nobuyasu (日) (読)
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| 6. | (英) Ueno Ichiro (日) (読)
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| 7. | (英) Saito Ken (日) (読)
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| 8. | 細井 英司
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| ○題名 (必須): | □ | (英) Flow Cytometric Evaluation of Surface CD56 Expression on Activated Natural Killer Cells as Functional Marker. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Surface CD56 is the most important cell marker for defining NK cells. However, the relationship between the expression of surface CD56 and NK cell activity has not yet been elucidated in detail. Thirteen healthy volunteers were enrolled in the present study. Peripheral blood mononuclear cells (PBMCs) were stimulated with rIL-2 or rIL-12 (1, 10, 100 U/mL) for 18 h at 37°C. After incubation, surface CD56 expression on NK cells was evaluated using a flow cytometric analysis. A colorimetric-based lactate dehydrogenase (LDH) assay was used for experiments on cytotoxicity. IFN- mRNA gene expression was quantified by real-time PCR. The expression level of surface CD56 on NK cells, cytotoxicity, and IFN- mRNA gene expression were significantly increased by the rIL-2 and rIL-12 stimulations. In addition, a positive correlation was found between surface CD56 expression and cytotoxic activity or IFN- mRNA gene expression. We revealed that the quantification of surface CD56 expression was applicable to the evaluation of cytotoxicity and IFN- production in activated NK cells. These results suggest that the measurement of surface CD56 expression represent an easy and rapidly reproducible technique to evaluate the activated state of NK cells and monitor NK cell activity in immunotherapy. J. Med. Invest. 63: 199-203, August, 2016. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1349-6867
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
(CiNii NCID)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 63
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| ○号 (必須): | □ | 3,4
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| ○頁 (必須): | □ | 199 203
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| ○年月日 (必須): | □ | 西暦 2016年 8月 初日 (平成 28年 8月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.63.199 (→Scopusで検索)
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| ○PMID (任意): | □ | 27644558 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-84987879967
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| ○機関リポジトリ : | □ | 111181
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) KeywordList.Keyword: Antibody-dependent cellular cytotoxicity (ADCC) (日)
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| 2. | (英) KeywordList.Keyword: Single nucleotide polymorphisms (SNPs) (日)
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