| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 北村 嘉章 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.耳鼻咽喉科・頭頸部外科学]/[徳島大学.病院.診療科.感覚·皮膚·運動機能科.耳鼻咽喉科・頭頸部外科])
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| 2. | 水口 博之
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| 3. | (英) Okamoto Kentaro (日) (読)
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| 4. | (英) Kitayama, Mika (日) (読)
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| 5. | 藤井 達也
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| 6. | (英) Fujioka, Akira (日) (読)
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| 7. | (英) Matsushita Toshio (日) (読)
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| 8. | 向井 孝志 ([日亜化学工業株式会社])
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| 9. | 久保 宜明 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.皮膚科学])
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| 10. | (英) Kubo Nobuo (日) (読)
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| 11. | 福井 裕行
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| 12. | 武田 憲昭
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| ○題名 (必須): | □ | (英) Irradiation with narrowband-ultraviolet B suppresses phorbol ester-induced up-regulation of H1 receptor mRNA in HeLa cells (日)
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| ○要約 (任意): | □ | (英) Conclusion These findings suggest that low dose irradiation with 310 nm NB-UVB specifically suppressed the up-regulation of H1R gene expression without inducing apoptosis and that UVB of shorter or longer wavelength than 310 nm NB-UVB had no such effects. Objective To develop a narrowband-ultraviolet B(NB-UVB) phototherapy for allergic rhinitis, this study investigated the effects of irradiation with NB-UVB at wavelength of 310 nm on phorbol-12-myristate-13-acetate (PMA)-induced up-regulation of histamine H1 receptor (H1R) mRNA in HeLa cells. Methods The mRNA levels of H1R in HeLa cells were measured using real-time RT-PCR. Apoptosis were evaluated with DNA fragmentation assay. Results PMA induced a significant increase in H1R mRNA expression in HeLa cells. Irradiation with 305 nm UVB and 310 nm NB-UVB, but not with 315 nm UVB at doses of 200 and 300 mJ/cm(2) significantly suppressed PMA-induced up-regulation of H1R mRNA. At a dose of 200 mJ/cm(2), irradiation with 305 nm UVB, but not with 310 nm NB-UVB, induced apoptosis, although exposure of the cells to both 305 and 310 nm UVB induced apoptosis at a dose of 300 mJ/cm(2) after PMA treatment in HeLa cells. Conversely, irradiation with 315 nm UVB at doses of 200 and 300 mJ/cm(2) did not induce apoptosis. (日)
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| ○キーワード (推奨): | 1. | (英) Epithelial Cells (日) (読)
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| 2. | (英) HeLa Cells (日) (読)
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| 3. | (英) Humans (日) (読)
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| 4. | (英) Phorbol Esters (日) (読)
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| 5. | (英) Receptors, Histamine H1 (日) (読)
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| 6. | (英) Rhinitis, Allergic (日) (読)
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| 7. | (英) Ultraviolet Therapy (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Acta Oto-Laryngologica ([Taylor & Francis])
(pISSN: 0001-6489, eISSN: 1651-2251)
| ○ISSN (任意): | □ | 1651-2251
ISSN: 0001-6489
(pISSN: 0001-6489, eISSN: 1651-2251) Title: Acta oto-laryngologicaTitle(ISO): Acta OtolaryngolPublisher: Taylor & Francis (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 136
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 409 413
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| ○年月日 (必須): | □ | 西暦 2016年 4月 初日 (平成 28年 4月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3109/00016489.2015.1129555 (→Scopusで検索)
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| ○PMID (任意): | □ | 26824787 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.3109/00016489.2015.1129555 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 4. | (英) KeywordList.Keyword: Histamine H1 receptor (日)
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| 5. | (英) KeywordList.Keyword: allergic rhinitis (日)
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| 6. | (英) KeywordList.Keyword: irradiation (日)
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| 7. | (英) KeywordList.Keyword: narrowband-ultraviolet B (日)
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| 8. | (英) KeywordList.Keyword: phototherapy (日)
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