| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Nakano Sei-ichi. (日) (読)
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| 2. | 岩﨑 英隆
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| 3. | 近藤 英司 ([徳島大学.病院.診療科.感覚·皮膚·運動機能科.耳鼻咽喉科・頭頸部外科])
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| 4. | 宮崎 かつし
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| 5. | 雫 治彦
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| 6. | (英) Kamimura Sei-ichirou (日) (読)
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| 7. | (英) Fukuda Junya (日) (読)
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| 8. | (英) Kanamura Ryou (日) (読)
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| 9. | 武田 憲昭
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| ○題名 (必須): | □ | (英) Efficacy of proton pump inhibitor in combination with rikkunshito in patients complaining of globus pharyngeus (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Globus pharyngeus (GP) is a common symptom of laryngopharyngeal reflux disease (LPRD), and proton pump inhibitor (PPI) and rikkunshito, a traditional Japanese medicine having prokinetic effect improve LPRD symptoms. In the present study, we examined the efficacy of high-dose PPI in combination with rikkunshito in patients complaining of GP. 106 patients complaining of GP without any organic endoscopic findings were enrolled. Patients were first administrated with high-dose PPI alone for 4 to 8 weeks and the symptom was improved in 65 patients. Among 41 patients with PPI-refractory GP, 22 patients were administrated with high-dose PPI in combination with rikkunshito, and the symptom was improved in 14 of 22 patients 4 weeks later. The average value of a modified reflux symptom index of the responders was similar to that of non-responders. Only a few patients had positive values in reflux finding scores in both groups. The present findings suggest the existence of a high prevalence of LPRD in patients complaining of GP. The data also suggest that gastroesophageal dysmotility is involved in GP, in addition to excessive acid reflux. The pre-therapeutic laryngopharyngeal symptoms and endoscopic findings could not predict the efficacy of the treatment for GP. J. Med. Invest. 63: 227-229, August, 2016. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1349-6867
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
(CiNii NCID)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 63
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| ○号 (必須): | □ | 3,4
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| ○頁 (必須): | □ | 227 229
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| ○年月日 (必須): | □ | 西暦 2016年 8月 初日 (平成 28年 8月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.63.227 (→Scopusで検索)
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| ○PMID (任意): | □ | 27644563 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-84987925216
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| ○機関リポジトリ : | □ | 111185
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.2152/jmi.63.227 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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