| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究)
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Ishikawa Eri (日) (読)
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| 2. | 小迫 英尊 ([徳島大学.先端酵素学研究所.基幹研究部門])
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| 3. | (英) Yasuda Tomoharu (日) (読)
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| 4. | (英) Ohmuraya Masaki (日) (読)
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| 5. | (英) Araki Kimi (日) (読)
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| 6. | (英) Kurosaki Tomohiro (日) (読)
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| 7. | (英) Saito Takashi (日) (読)
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| 8. | (英) Yamasaki Sho (日) (読)
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| ○題名 (必須): | □ | (英) Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Thymic selection shapes an appropriate T cell antigen receptor (TCR) repertoire during T cell development. Here, we show that a serine/threonine kinase, protein kinase D (PKD), is crucial for thymocyte positive selection. In T cell-specific PKD-deficient (PKD2/PKD3 double-deficient) mice, the generation of CD4 single positive thymocytes is abrogated. This defect is likely caused by attenuated TCR signalling during positive selection and incomplete CD4 lineage specification in PKD-deficient thymocytes; however, TCR-proximal tyrosine phosphorylation is not affected. PKD is activated in CD4(+)CD8(+) double positive (DP) thymocytes on stimulation with positively selecting peptides. By phosphoproteomic analysis, we identify SH2-containing protein tyrosine phosphatase-1 (SHP-1) as a direct substrate of PKD. Substitution of wild-type SHP-1 by phosphorylation-defective mutant (SHP-1(S557A)) impairs generation of CD4(+) thymocytes. These results suggest that the PKD-SHP-1 axis positively regulates TCR signalling to promote CD4(+) T cell development. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Nature Communications ([Nature Publishing Group])
(eISSN: 2041-1723)
| ○ISSN (任意): | □ | 2041-1723
ISSN: 2041-1723
(eISSN: 2041-1723) Title: Nature communicationsTitle(ISO): Nat CommunPublisher: Nature Portfolio (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 7
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 12756 12756
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 9月 27日 (平成 28年 9月 27日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/ncomms12756 (→Scopusで検索)
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| ○PMID (任意): | □ | 27670070 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS : | □ | 000385382100002
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| ○Scopus (任意): |
| ○機関リポジトリ : | □ | 112446
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1038/ncomms12756 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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