| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Sekita Yasuko (日) 関田 泰子 (読) せきた やすこ
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 村上 圭史
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| 3. | 湯本 浩通 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
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| 4. | 天羽 崇
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| ○学籍番号 (推奨): | □ | ****
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| 5. | 藤原 奈津美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健医療管理学])
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| ○学籍番号 (推奨): | □ | ****
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| 6. | (英) Ogata Shohei (日) 小方 昌平 (読) おがた しょうへい
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| ○学籍番号 (推奨): | □ | ****
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| 7. | 松尾 敬志
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| 8. | 三宅 洋一郎
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| 9. | 柏田 良樹
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| ○題名 (必須): | □ | (英) Preventive Effects of Houttuynia cordata Extract for Oral Infectious Diseases. (日)
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| ○要約 (任意): | □ | (英) Houttuynia cordata (HC) (Saururaceae) has been used internally and externally as a traditional medicine and as an herbal tea for healthcare in Japan. Our recent survey showed that HC poultice (HCP) prepared from smothering fresh leaves of HC had been frequently used for the treatment of purulent skin diseases with high effectiveness. Our experimental study also demonstrated that ethanol extract of HCP (eHCP) has antibacterial, antibiofilm, and anti-inflammatory effects against S. aureus which caused purulent skin diseases. In this study, we focused on novel effects of HCP against oral infectious diseases, such as periodontal disease and dental caries. We determined the antimicrobial and antibiofilm effects of water solution of HCP ethanol extract (wHCP) against important oral pathogens and investigated its cytotoxicity and anti-inflammatory effects on human oral epithelial cells. wHCP had moderate antimicrobial effects against some oral microorganisms and profound antibiofilm effects against Fusobacterium nucleatum, Streptococcus mutans, and Candida albicans. In addition, wHCP had no cytotoxic effects and could inhibit interleukin-8 and CCL20 productions by Porphyromonas gingivalis lipopolysaccharide-stimulated human oral keratinocytes. Our findings suggested that wHCP may be clinically useful for preventing oral infectious diseases as a mouthwash for oral care. (日)
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| ○キーワード (推奨): | 1. | (英) Anti-Bacterial Agents (日) (読)
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| 2. | 細菌 (bacteria)
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| 3. | (英) Biofilms (日) (読)
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| 4. | (英) Cell Line (日) (読)
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| 5. | (英) Cell Survival (日) (読)
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| 6. | (英) Dental Caries (日) (読)
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| 7. | (英) Houttuynia (日) (読)
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| 8. | (英) Humans (日) (読)
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| 9. | (英) Periodontal Diseases (日) (読)
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| 10. | (英) Plant Extracts (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | BioMed Research International (Hindawi Pub. Co.)
(pISSN: 2314-6133, eISSN: 2314-6141)
| ○ISSN (任意): | □ | 2314-6141
ISSN: 2314-6133
(pISSN: 2314-6133, eISSN: 2314-6141) Title: BioMed research internationalTitle(ISO): Biomed Res IntPublisher: Hindawi (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 2016
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 2581876 2581876
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 6月 20日 (平成 28年 6月 20日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1155/2016/2581876 (→Scopusで検索)
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| ○PMID (任意): | □ | 27413739 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-84978765486
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| ○機関リポジトリ : | □ | 112384
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1155/2016/2581876 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) OtherID: PMC4931051 (日)
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