| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Igami Kentaro (日) (読)
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| 2. | (英) Shimojo Yosuke (日) (読)
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| 3. | (英) Ito Hisatomi (日) (読)
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| 4. | (英) Miyazaki Toshitsugu (日) (読)
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| 5. | (英) Nakano Fusako (日) (読)
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| 6. | 柏田 良樹
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| ○題名 (必須): | □ | (英) Fermented Ginseng Contains an Agonist of Peroxisome Proliferator Activated Receptors and . (日)
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| ○要約 (任意): | □ | (英) Peroxisome proliferator activated receptor (PPAR) is a nuclear receptor that is one of the transcription factors regulating lipid and glucose metabolism. Fermented ginseng (FG) is a ginseng fermented by Lactobacillus paracasei A221 containing minor ginsenosides and metabolites of fermentation. DNA microarray analysis of rat liver treated with FG indicated that FG affects on lipid metabolism are mediated by PPAR-. To identify a PPAR- agonist in FG, PPAR- transcription reporter assay-guided fractionation was performed. The fraction obtained from the MeOH extract of FG, which showed potent transcription activity of PPAR-, was fractionated by silica gel column chromatography into 16 subfractions, and further separation and crystallization gave compound 1 together with four known constituents of ginseng, including 20(R)- and 20(S)-protopanaxadiol, and 20(R)- and 20(S)-ginsenoside Rh1. The structure of compound 1 was identified as 10-hydroxy-octadecanoic acid by (1)H- and (13)C-NMR spectra and by EI-MS analysis of the methyl ester of 1. Compound 1 demonstrated much higher transcription activity of PPAR- than the other isolated compounds. In addition, compound 1 also showed 5.5-fold higher transcription activity of PPAR- than vehicle at the dose of 20 g/mL. In the present study, we identified 10-hydroxy-octadecanoic acid as a dual PPAR-/ agonist in FG. Our study suggested that metabolites of fermentation, in addition to ginsenosides, contribute to the health benefits of FG. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Journal of Medicinal Food (Mary Ann Liebert, Inc.)
(pISSN: 1096-620X, eISSN: 1557-7600)
| ○ISSN (任意): | □ | 1557-7600
ISSN: 1096-620X
(pISSN: 1096-620X, eISSN: 1557-7600) Title: Journal of medicinal foodTitle(ISO): J Med FoodPublisher: SAGE Publications (NLM Catalog)
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| ○巻 (必須): | □ | 19
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | 817 822
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 9月 初日 (平成 28年 9月 初日)
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| ○DOI (任意): | □ | 10.1089/jmf.2016.3673 (→Scopusで検索)
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| ○PMID (任意): | □ | 27627700 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1089/jmf.2016.3673 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: 10-hydroxy-octadecanoic acid (日)
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| 4. | (英) KeywordList.Keyword: DNA microarray (日)
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| 5. | (英) KeywordList.Keyword: PPAR alpha (日)
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| 6. | (英) KeywordList.Keyword: PPAR gamma (日)
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| 7. | (英) KeywordList.Keyword: fermented ginseng (日)
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