| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Tanaka A (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Murohara T (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Taguchi I (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Eguchi K (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Suzuki M (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Kitakaze M (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Sato Y (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Ishizu T (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 9. | (英) Higashi Y (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 10. | 山田 博胤 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 11. | (英) Nanasato M (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 12. | 島袋 充生
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 13. | (英) Teragawa H (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 14. | (英) Ueda S (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 15. | (英) Kodera S (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 16. | 松久 宗英 ([徳島大学.先端酵素学研究所.基幹研究部門]/徳島大学病院アンチエイジングセンター センター長(併任)/徳島大学先端酵素学研究所長(併任))
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 17. | (英) Kadokami T (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 18. | (英) Kario K (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 19. | (英) Nishio Y (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 20. | (英) Inoue T (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 21. | (英) Maemura K (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 22. | (英) Oyama J (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 23. | (英) Ohishi M (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 24. | 佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 25. | (英) Tomiyama H (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 26. | (英) Node K (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 27. | (英) PROTECT Study Investigators (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Rationale and design of a multicenter randomized controlled study to evaluate the preventive effect of ipragliflozin on carotid atherosclerosis: the PROTECT study. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) BACKGROUND: Type 2 diabetes mellitus is associated strongly with an increased risk of micro- and macro-vascular complications, leading to impaired quality of life and shortened life expectancy. In addition to appropriate glycemic control, multi-factorial intervention for a wide range of risk factors, such as hypertension and dyslipidemia, is crucial for management of diabetes. A recent cardiovascular outcome trial in diabetes patients with higher cardiovascular risk demonstrated that a SGLT2 inhibitor markedly reduced mortality, but not macro-vascular events. However, to date there is no clinical evidence regarding the therapeutic effects of SGLT2 inhibitors on arteriosclerosis. The ongoing PROTECT trial was designed to assess whether the SGLT2 inhibitors, ipragliflozin, prevented progression of carotid intima-media thickness in Japanese patients with type 2 diabetes mellitus.METHODS: A total of 480 participants with type 2 diabetes mellitus with a HbA1c between 6 and 10 % despite receiving diet/exercise therapy and/or standard anti-diabetic agents for at least 3 months, will be randomized systematically (1:1) into either ipragliflozin or control (continuation of conventional therapy) groups. After randomization, ipragliflozin (50-100 mg once daily) will be added on to the background therapy in participants assigned to the ipragliflozin group. The primary endpoint of the study is the change in mean intima-media thickness of the common carotid artery from baseline to 24 months. Images of carotid intima-media thickness will be analyzed at a central core laboratory in a blinded manner. The key secondary endpoints include the change from baseline in other parameters of carotid intima-media thickness, various metabolic parameters, and renal function. Other cardiovascular functional tests are also planned for several sub-studies.DISCUSSION: The PROTECT study is the first to assess the preventive effect of ipragliflozin on progression of carotid atherosclerosis using carotid intima-media thickness as a surrogate marker. The study has potential to clarify the protective effects of ipragliflozin on atherosclerosis. Trial registration Unique Trial Number, UMIN000018440 ( https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000021348 ). (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
| [継承] |
| 2. | (英) Aged (日) (読)
| [継承] |
| 3. | (英) Biomarkers (日) (読)
| [継承] |
| 4. | (英) Carotid Artery Diseases (日) (読)
| [継承] |
| 5. | (英) Carotid Artery, Common (日) (読)
| [継承] |
| 6. | (英) Carotid Intima-Media Thickness (日) (読)
| [継承] |
| 7. | (英) Clinical Protocols (日) (読)
| [継承] |
| 8. | (英) Diabetes Mellitus, Type 2 (日) (読)
| [継承] |
| 9. | (英) Diabetic Angiopathies (日) (読)
| [継承] |
| 10. | (英) Drug Therapy, Combination (日) (読)
| [継承] |
| 11. | (英) Female (日) (読)
| [継承] |
| 12. | (英) Glucosides (日) (読)
| [継承] |
| 13. | (英) Hemoglobin A, Glycosylated (日) (読)
| [継承] |
| 14. | (英) Humans (日) (読)
| [継承] |
| 15. | (英) Hypoglycemic Agents (日) (読)
| [継承] |
| 16. | (英) Japan (日) (読)
| [継承] |
| 17. | (英) Male (日) (読)
| [継承] |
| 18. | (英) Middle Aged (日) (読)
| [継承] |
| 19. | (英) Prospective Studies (日) (読)
| [継承] |
| 20. | (英) Research Design (日) (読)
| [継承] |
| 21. | (英) Sodium-Glucose Transporter 2 (日) (読)
| [継承] |
| 22. | (英) Thiophenes (日) (読)
| [継承] |
| 23. | (英) Time Factors (日) (読)
| [継承] |
| 24. | (英) Treatment Outcome (日) (読)
| [継承] |
| 25. | (英) Young Adult (日) (読)
| [継承] |
| ○発行所 (推奨): | □ | BioMed Central Ltd.
| [継承] |
| ○誌名 (必須): | □ | Cardiovascular Diabetology ([BioMed Central Ltd.])
(eISSN: 1475-2840)
| ○ISSN (任意): | □ | 1475-2840
ISSN: 1475-2840
(eISSN: 1475-2840) Title: Cardiovascular diabetologyTitle(ISO): Cardiovasc DiabetolPublisher: BioMed Central (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 15
| [継承] |
| ○号 (必須): | □ | 1
| [継承] |
| ○頁 (必須): | □ | 133 133
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 9月 13日 (平成 28年 9月 13日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1186/s12933-016-0449-7 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 27619983 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1186/s12933-016-0449-7 (日)
| [継承] |
| 2. | (英) Article.DataBankList.DataBank.DataBankName: UMIN CTR (日)
| [継承] |
| 3. | (英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: JPRN/UMIN000018440 (日)
| [継承] |
| 4. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 5. | (英) Article.PublicationTypeList.PublicationType: Multicenter Study (日)
| [継承] |
| 6. | (英) Article.PublicationTypeList.PublicationType: Randomized Controlled Trial (日)
| [継承] |
| 7. | (英) OtherID: PMC5020545 (日)
| [継承] |
| 8. | (英) KeywordList.Keyword: Atherosclerosis (日)
| [継承] |
| 9. | (英) KeywordList.Keyword: Intima-media thickness (IMT) (日)
| [継承] |
| 10. | (英) KeywordList.Keyword: Ipragliflozin (日)
| [継承] |
| 11. | (英) KeywordList.Keyword: SGLT2 inhibitor (日)
| [継承] |
| 12. | (英) KeywordList.Keyword: Type 2 diabetes mellitus (日)
| [継承] |