| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Hasegawa K (日) (読)
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| 2. | (英) Tagawa M (日) (読)
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| 3. | (英) Takagi K (日) (読)
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| 4. | (英) Tsukamoto H (日) (読)
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| 5. | (英) Tomioka Y (日) (読)
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| 6. | (英) Suzuki T (日) (読)
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| 7. | 西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
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| 8. | (英) Ohrui T (日) (読)
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| 9. | (英) Numasaki M (日) (読)
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| ○題名 (必須): | □ | (英) Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-λ2 or IL-29/IFN-λ1. (日)
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| ○要約 (任意): | □ | (英) Interleukin (IL)-28A/interferon (IFN)-λ2 and IL-29/IFN-λ1 have been demonstrated to elicit direct and indirect anti-tumor actions. In this study, we constructed an adenovirus vector expressing either IL-28A/IFN-λ2 (AdIL-28A) or IL-29/IFN-λ1 (AdIL-29) to evaluate the therapeutic properties of intratumoral injection of recombinant adenovirus to apply for the clinical implementation of cancer gene therapy. Despite the lack of an anti-proliferative effect on MCA205 and B16-F10 cells, a retarded growth of established subcutaneous tumors was observed following multiple injections of either AdIL-28A or AdIL-29 when compared with AdNull. In vivo cell depletion experiments displayed that both NK cells and CD8(+) T cells have a major role in AdIL-28A-mediated tumor growth suppression. A significant increase in the number of infiltrating CD8(+) T cells into the tumors treated with either AdIL-28A or AdIL-29 was observed. Moreover, specific anti-tumor cytotoxic T lymphocyte reactivity was detected in spleen cells from animals treated with either AdIL-28A or AdIL-29. In IFN-γ-deficient mice, anti-tumor activities of AdIL-28A were completely impaired, indicating that IFN-γ is critically involved in the tumor growth inhibition triggered by AdIL-28A. IL-12 provided a synergistic anti-tumor effect when combined with AdIL-28A. These results indicate that AdIL-28A and AdIL-29 could be successfully utilized as an alternative cancer immunogene therapy. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Cancer Gene Therapy ([Nature Publishing Group])
(pISSN: 0929-1903, eISSN: 1476-5500)
| ○ISSN (任意): | □ | 1476-5500
ISSN: 0929-1903
(pISSN: 0929-1903, eISSN: 1476-5500) Title: Cancer gene therapyTitle(ISO): Cancer Gene TherPublisher: Springer Nature (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 23
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| ○号 (必須): | □ | 8
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| ○頁 (必須): | □ | 266 277
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| ○年月日 (必須): | □ | 西暦 2016年 8月 19日 (平成 28年 8月 19日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/cgt.2016.29 (→Scopusで検索)
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| ○PMID (任意): | □ | 27561689 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1038/cgt.2016.29 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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