| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): | □ | Peer Review
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kamada Chiemi (日) 鎌田 智英実 (読) かまだ ちえみ
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 向井 理恵 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系.食料科学分野])
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| 3. | (英) Kondo Akari (日) 近藤 あかり (読) こんどう あかり
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| ○学籍番号 (推奨): | □ | ****
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| 4. | (英) Sato Shinya (日) 佐藤 伸哉 (読) さとう しんや
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| ○学籍番号 (推奨): | □ | ****
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| 5. | 寺尾 純二
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| ○題名 (必須): | □ | (英) Effect of quercetin and its metabolite on caveolin-1 expression induced by oxidized LDL and lysophosphatidylcholine in endothelial cells. (日)
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| ○要約 (任意): | □ | (英) Oxidized low-density lipoprotein contributes to atherosclerotic plaque formation, and quercetin is expected to exert anti-atherosclerotic effects. We previously reported accumulation of conjugated quercetin metabolites in the aorta of rabbits fed high-cholesterol diets with quercetin glucosides, resulting in attenuation of lipid peroxidation and inhibition of lipid accumulation. Caveolin-1, a major structural protein of caveolae in vascular endothelial cells, plays a role in atherosclerosis development. Here we investigated effects of oxidized low-density lipoprotein, quercetin and its metabolite, quercetin 3-O--glucuronide, on caveolin-1 expression. Oxidized low-density lipoprotein significantly upregulated caveolin-1 mRNA expression. An oxidized low-density lipoprotein component, lysophosphatidylcholine, also induced expression of both caveolin-1 mRNA and protein. However, lysophosphatidylcholine did not affect the location of caveolin-1 proteins within caveolae structures. Co-treatment with quercetin or quercetin 3-O--glucuronide inhibited lysophosphatidylcholine-induced caveolin-1 expression. Quercetin and quercetin 3-O--glucuronide also suppressed expression of adhesion molecules induced by oxidized low-density lipoprotein and lysophosphatidylcholine. These results strongly suggest lysophosphatidylcholine derived from oxidized low-density lipoprotein contributes to atherosclerotic events by upregulating caveolin-1 expression, resulting in induction of adhesion molecules. Quercetin metabolites are likely to exert an anti-atherosclerotic effect by attenuating caveolin-1 expression in endothelial cells. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Clinical Biochemistry and Nutrition (日本酸化ストレス学会)
(pISSN: 0912-0009, eISSN: 1880-5086)
| ○ISSN (任意): | □ | 0912-0009
ISSN: 0912-0009
(pISSN: 0912-0009, eISSN: 1880-5086) Title: Journal of clinical biochemistry and nutritionTitle(ISO): J Clin Biochem NutrSupplier: 一般社団法人 日本酸化ストレス学会Publisher: The Society for Free Radical Research Japan (NLM Catalog)
(医中誌Web)
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(Scopus)
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| ○巻 (必須): | □ | 58
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 193 201
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 4月 16日 (平成 28年 4月 16日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3164/jcbn.16-2 (→Scopusで検索)
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| ○PMID (任意): | □ | 27257344 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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