| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Nuka Erika (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Tomono Susumu (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Ishisaka Akari (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Kato Yoji (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Miyoshi Noriyuki (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | 河合 慶親
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Metal-catalyzed oxidation of 2-alkenals generates genotoxic 4-oxo-2-alkenals during lipid peroxidation. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Lipid peroxidation products react with cellular molecules, such as DNA bases, to form covalent adducts, which are associated with aging and disease processes. Since lipid peroxidation is a complex process and occurs in multiple stages, there might be yet unknown reaction pathways. Here, we analyzed comprehensively 2'-deoxyguanosine (dG) adducts with oxidized arachidonic acid using liquid chromatography-tandem mass spectrometry and found the formation of 7-(2-oxo-hexyl)-etheno-dG as one of the major unidentified adducts. The formation of this adduct was reproduced in the reaction of dG with 2-octenal and predominantly with 4-oxo-2-octenal (OOE). We also found that other 2-alkenals (with five or more carbons) generate corresponding 4-oxo-2-alkenal-type adducts. Importantly, it was found that transition metals enhanced the oxidation of C4-position of 2-octenal, leading to the formation of OOE-dG adduct. These findings demonstrated a new pathway for the formation of 4-oxo-2-alkenals during lipid peroxidation and might provide a mechanism for metal-catalyzed genotoxicity. (日)
| [継承] |
| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Bioscience, Biotechnology, and Biochemistry ([社団法人 日本農芸化学会])
(pISSN: 0916-8451, eISSN: 1347-6947)
| ○ISSN (任意): | □ | 1347-6947
ISSN: 0916-8451
(pISSN: 0916-8451, eISSN: 1347-6947) Title: Bioscience, biotechnology, and biochemistryTitle(ISO): Biosci Biotechnol BiochemSupplier: 社団法人日本農芸化学会Publisher: Oxford University Press (NLM Catalog)
(CiNii NCID)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 80
| [継承] |
| ○号 (必須): | □ | 10
| [継承] |
| ○頁 (必須): | □ | 2007 2013
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 6月 7日 (平成 28年 6月 7日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1080/09168451.2016.1191334 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 27281652 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-84986277540
| [継承] |
| ○機関リポジトリ : | □ | 111121
| [継承] |
| ○researchmap (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
| [継承] |