| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Wittayarat Manita (日) (読)
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| 2. | (英) Sato Yoko (日) (読)
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| 3. | (英) Do Lanh Thi Kim (日) (読)
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| 4. | (英) Chatdarong Kaywalee (日) (読)
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| 5. | (英) Tharasanit Theerawat (日) (読)
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| 6. | (英) Techakumphu Mongkol (日) (読)
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| 7. | (英) Taniguchi Masayasu (日) (読)
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| 8. | 音井 威重
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| ○題名 (必須): | □ | (英) Epigenetic modulation on cat-cow interspecies somatic cell nuclear transfer embryos by treatment with trichostatin A. (日)
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| ○要約 (任意): | □ | (英) This study aimed to determine the acetylation at lysine 9/18/23 of histone H3 (H3K9ac/H3K18ac/H3K23ac; H3K9/18/23 ac) and the di-methylation at lysine 9 of histone H3 (H3K9me2) during early embryogenesis among trichostatin A (TSA)-treated interspecies somatic cell nuclear transfer (iSCNT) cat-cow (TSA-iSCNT) embryos, TSA-untreated iSCNT cat-cow control (control) embryos and bovine in vitro fertilization (IVF) embryos, because TSA-iSCNT embryos can develop to blastocysts. Compared to the control embryos, higher expressions of H3K9/18/23 ac were observed in TSA-iSCNT embryos and IVF embryos at most following stages (2 h post-fusion / post-insemination (PF/PI) to eight-cell stage). At 6 h PF/PI the expression of H3K9/23 ac in TSA-iSCNT embryos and IVF embryos were lower than those in control embryos, and the expression of H3K18ac was no difference among the three groups. The expression of H3K9/23 ac increased in TSA-iSCNT embryos and IVF embryos at pronuclear (PN) stages. The expression of H3K9me2 in TSA-iSCNT embryos resembled that of IVF embryos at 2 h PF/PI to PN stages, and these expression levels were greater than those of control embryos. These results suggest that treatment of iSCNT embryos with TSA modifies the patterns of histone modification at certain lysine residues in a manner that is comparable with that seen in IVF during early embryogenesis. (日)
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| ○誌名 (必須): | □ | Animal Science Journal (日本畜産学会)
(pISSN: 1344-3941, eISSN: 1740-0929)
| ○ISSN (任意): | □ | 1740-0929
ISSN: 1344-3941
(pISSN: 1344-3941, eISSN: 1740-0929) Title: Animal science journal = Nihon chikusan GakkaihoTitle(ISO): Anim Sci JSupplier: Japanese Society of Animal SciencePublisher: Wiley Publishing (NLM Catalog)
(医中誌Web)
(Wiley)
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| ○年月日 (必須): | □ | 西暦 2016年 8月 9日 (平成 28年 8月 9日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/asj.12676 (→Scopusで検索)
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| ○PMID (任意): | □ | 27506538 (→Scopusで検索)
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| ○Scopus (任意): | 1. | 2-s2.0-84982920557
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| ○備考 (任意): | 1. | (英) PublicationType: JOURNAL ARTICLE (日)
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