| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究)
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Bae R. Heekyong (日) (読)
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| 2. | (英) Leung S. C. Patrick (日) (読)
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| 3. | 常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
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| 4. | (英) Valencia C. Julio (日) (読)
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| 5. | (英) Hodge L. Deborah (日) (読)
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| 6. | (英) Kim Seohyun (日) (読)
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| 7. | (英) Back Tim (日) (読)
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| 8. | (英) Karwan Megan (日) (読)
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| 9. | (英) Merchant S. Anand (日) (読)
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| 10. | (英) Baba Nobuyuki (日) (読)
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| 11. | (英) Feng Dechun (日) (読)
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| 12. | (英) Park Ogyi (日) (読)
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| 13. | (英) Gao Bin (日) (読)
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| 14. | (英) Yang Guo-Xiang (日) (読)
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| 15. | (英) Eric Gershwin M (日) (読)
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| 16. | (英) Young A. Howard (日) (読)
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| ○題名 (必須): | □ | (英) Chronic Expression of Interferon Gamma Leads to Murine Autoimmune Cholangitis with a Female Predominance. (日)
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| ○要約 (任意): | □ | (英) In most autoimmune diseases the serologic hallmarks of disease precede clinical pathology by years. Therefore the use of animal models in defining early disease events becomes critical. Herein we have taken advantage of a "designer" mouse with dysregulation of interferon gamma (IFN) characterized by prolonged and chronic expression of IFN through deletion of the IFN 3' UTR AU-rich element. These mice develop primary biliary cholangitis (PBC) with a female predominance that mimics human disease and is characterized by upregulation of total bile acids, spontaneous production of AMA, and portal duct inflammation. Transfer of CD4 T cells from ARE-Del-/- to B6/Rag1(-/-) mice induced moderate portal inflammation, and parenchymal inflammation, RNA-sequencing of liver gene expression revealed that upregulated genes potentially define early stages of cholangitis. Interestingly, upregulated genes specifically overlap with the gene expression signature of biliary epithelial cells in PBC, implying that IFN may play a pathogenic role in biliary epithelial cells (BEC) in the initiation stage of PBC. Moreover, differentially expressed genes in female mice have stronger Type I and II interferon signaling and lymphocyte-mediated immune responses and thus may drive the female bias of the disease. In conclusion, changes in IFN expression are critical for the pathogenesis of PBC. This article is protected by copyright. All rights reserved. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Hepatology (American Association for the Study of Liver Diseases)
(pISSN: 0270-9139, eISSN: 1527-3350)
| ○ISSN (任意): | □ | 1527-3350
ISSN: 0270-9139
(pISSN: 0270-9139, eISSN: 1527-3350) Title: Hepatology (Baltimore, Md.)Title(ISO): HepatologySupplier: American Association for the Study of Liver DiseasesPublisher: Wiley (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 64
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 1189 1201
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 5月 14日 (平成 28年 5月 14日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1002/hep.28641 (→Scopusで検索)
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| ○PMID (任意): | □ | 27178326 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS : | □ | 000384552300018
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| ○Scopus (任意): | 1. | 2-s2.0-84988421413
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1002/hep.28641 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: JOURNAL ARTICLE (日)
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| 3. | (英) KeywordList.Keyword: CD4 T cells (日)
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| 4. | (英) KeywordList.Keyword: MHC Class II (日)
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| 5. | (英) KeywordList.Keyword: autoimmune diseases (日)
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| 6. | (英) KeywordList.Keyword: interferons (日)
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| 7. | (英) KeywordList.Keyword: sex-biased (日)
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