| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | 髙橋 徹行
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| 2. | (英) Nishida Takeshi (日) (読)
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| 3. | (英) Baba Hayato (日) (読)
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| 4. | (英) Hatta Hideki (日) (読)
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| 5. | (英) Imura Johji (日) (読)
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| 6. | (英) Sutoh Mitsuko (日) (読)
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| 7. | (英) Toyohara Syunji (日) (読)
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| 8. | (英) Hokao Ryoji (日) (読)
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| 9. | (英) Watanabe Syunsuke (日) (読)
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| 10. | 小川 博久 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
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| 11. | 上原 久典 ([徳島大学.病院.診療科.病理診断科])
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| 12. | 常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
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| ○題名 (必須): | □ | (英) Histopathological characteristics of glutamine synthetase-positive hepatic tumor lesions in a mouse model of spontaneous metabolic syndrome (TSOD mouse). (日)
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| ○要約 (任意): | □ | (英) We previously reported that Tsumura-Suzuki obese diabetic (TSOD) mice, a polygenic model of spontaneous type 2 diabetes, is a valuable model of hepatic carcinogenesis via non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). One of the characteristics of tumors in these mice is the diffuse expression of glutamine synthetase (GS), which is a diagnostic marker for hepatocellular carcinoma (HCC). In this study, we performed detailed histopathological examinations and found that GS expression was diffusely positive in >70% of the hepatic tumors from 15-month-old male TSOD mice. Translocation of -catenin into nuclei with enhanced membranous expression also occurred in GS-positive tumors. Small lesions (<1 mm) in GS-positive cases exhibited dysplastic nodules, with severe nuclear atypia, whereas large lesions (>3 mm) bore the characteristics of human HCC, exhibiting nuclear and structural atypia with invasive growth. By contrast, the majority of GS-negative tumors were hepatocellular adenomas with advanced fatty change and low nuclear grade. In GS-negative tumors, loss of liver fatty acid-binding protein expression was observed. These results suggest that the histological characteristics of GS-positive hepatic tumors in TSOD mice resemble human HCC; thus, this model may be a useful tool in translational research targeting the NAFLD/NASH-HCC sequence. (日)
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| ○誌名 (必須): | □ | Molecular and Clinical Oncology (Spandidos Publications UK Ltd)
(pISSN: 2049-9450, eISSN: 2049-9469)
| ○ISSN (任意): | □ | 2049-9450
ISSN: 2049-9450
(pISSN: 2049-9450, eISSN: 2049-9469) Title: Molecular and clinical oncologyTitle(ISO): Mol Clin OncolPublisher: Spandidos Publications (NLM Catalog)
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| ○巻 (必須): | □ | 5
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 267 270
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 6月 9日 (平成 28年 6月 9日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3892/mco.2016.924 (→Scopusで検索)
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| ○PMID (任意): | □ | 27446562 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: JOURNAL ARTICLE (日)
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