| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kamezaki Chihiro (日) (読)
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| 2. | (英) Nakashima Ami (日) (読)
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| 3. | (英) Yamada Asako (日) (読)
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| 4. | (英) Uenishi Sachiko (日) (読)
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| 5. | (英) Ishibashi Hiroshi (日) (読)
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| 6. | (英) Shibuya Natsumi (日) (読)
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| 7. | (英) Hama Susumu (日) (読)
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| 8. | (英) Hosoi Shinzo (日) (読)
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| 9. | (英) Yamashita Eiji (日) (読)
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| 10. | 小暮 健太朗 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学])
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| ○題名 (必須): | □ | (英) Synergistic antioxidative effect of astaxanthin and tocotrienol by co-encapsulated in liposomes (日)
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| ○要約 (任意): | □ | (英) Astaxanthin and vitamin E are both effective antioxidants that are frequently used in cosmetics, as food additives, and in to prevent oxidative damage. A combination of astaxanthin and vitamin E would be expected to show an additive anntioxidative effect. In this study, liposomes co-encapsulating astaxanthin and the vitamin E derivatives α-tocopherol (α-T) or tocotrienols (T3) were prepared, and the antioxidative activity of these liposomes toward singlet oxygen and hydroxyl radical was evaluated in vitro. Liposomes co-encapsulating astaxanthin and α-T showed no additive anntioxidative effect, while the actual scavenging activity of liposomes co-encapsulating astaxanthin and T3 was higher than the calculated additive activity. To clarify why this synergistic effect occurs, the most stable structure of astaxanthin in the presence of α-T or α-T3 was calculated. Only α-T3 was predicted to form hydrogen bonding with astaxanthin, and the astaxanthin polyene chain would partially interact with the α-T3 triene chain, which could explain why there was a synergistic effect between astaxanthin and T3 but not α-T. In conclusion, co-encapsulation of astaxanthin and T3 induces synergistic scavenging activity by intermolecular interactions between the two antioxidants. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Clinical Biochemistry and Nutrition (日本酸化ストレス学会)
(pISSN: 0912-0009, eISSN: 1880-5086)
| ○ISSN (任意): | □ | 0912-0009
ISSN: 0912-0009
(pISSN: 0912-0009, eISSN: 1880-5086) Title: Journal of clinical biochemistry and nutritionTitle(ISO): J Clin Biochem NutrSupplier: 一般社団法人 日本酸化ストレス学会Publisher: The Society for Free Radical Research Japan (NLM Catalog)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 59
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 100 106
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 4月 15日 (平成 28年 4月 15日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3164/jcbn.15-153 (→Scopusで検索)
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| ○PMID (任意): | □ | 27698536 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS : | □ | 000384952500004
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| ○Scopus (任意): | 1. | 2-s2.0-84988934724
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| ○機関リポジトリ : | □ | 110843
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) KeywordList.Keyword: astaxanthin (日)
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| 3. | (英) KeywordList.Keyword: intermolecular interaction (日)
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| 4. | (英) KeywordList.Keyword: synergistic activity (日)
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| 5. | (英) KeywordList.Keyword: tocotrienol (日)
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| 6. | (英) KeywordList.Keyword: vitamin E (日)
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