| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kuse Kyohei (日) (読)
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| 2. | (英) Ito Jumpei (日) (読)
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| 3. | (英) Miyake Ariko (日) (読)
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| 4. | (英) Kawasaki Junna (日) (読)
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| 5. | (英) Watanabe Shinya (日) (読)
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| 6. | (英) Makundi Isaac (日) (読)
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| 7. | (英) Ngo Minh Ha (日) (読)
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| 8. | 音井 威重
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| 9. | (英) Nishigaki Kazuo (日) (読)
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| ○題名 (必須): | □ | (英) Existence of two distinct infectious ERVs in domestic cats and their different strategies for adaptation to transcriptional regulation. (日)
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| ○要約 (任意): | □ | (英) The domestic cat genome contains many endogenous retroviruses, including ERV-DCs. These ERV-DCs have been acquired through germ cell infections with exogenous retroviruses. Some of these ERV-DCs are still capable of producing infectious virions. Hosts must tightly control these ERVs because replication-competent viruses in the genome pose a risk to the host. Here, we investigated how ERV-DCs are adapted by their hosts. Replication-competent viruses with strong promoter activity such as ERV-DC10 and ERV-DC18 were suppressed by promoter methylation in LTRs. On the other hand, replication-competent virus with weak promoter activity such as ERV-DC14 seemed to escape from strict control via promoter methylation by the host. Interestingly, ERV-DCs with weak promoter activity such as ERV-DC14 have expanded in the cat genome significantly more than ERV-DCs with strong promoter activity. Our results improve understanding of the host-virus conflict and how ERVs adapt in their hosts over time. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Virology ([アメリカ微生物学会])
(pISSN: 0022-538X, eISSN: 1098-5514)
| ○ISSN (任意): | □ | 1098-5514
ISSN: 0022-538X
(pISSN: 0022-538X, eISSN: 1098-5514) Title: Journal of virologyTitle(ISO): J VirolPublisher: American Society for Microbiology (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): |
| ○号 (必須): |
| ○頁 (必須): |
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| ○年月日 (必須): | □ | 西暦 2016年 7月 27日 (平成 28年 7月 27日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1128/JVI.00716-16 (→Scopusで検索)
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| ○PMID (任意): | □ | 27466428 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: JOURNAL ARTICLE (日)
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