| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Nakamura Toru (日) (読)
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| 2. | 片桐 豊雅
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| 3. | (英) Sato Shoki (日) (読)
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| 4. | (英) Kushibiki Toshihiro (日) (読)
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| 5. | (英) Hontani Koji (日) (読)
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| 6. | (英) Tsuchikawa Takahiro (日) (読)
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| 7. | (英) Hirano Satoshi (日) (読)
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| 8. | (英) Nakamura Yusuke (日) (読)
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| ○題名 (必須): | □ | (英) Overexpression of C16orf74 is involved in aggressive pancreatic cancers. (日)
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| ○要約 (任意): | □ | (英) Clinical outcome of pancreatic ductal adenocarcinoma (PDAC) has not been improved in the last three decades due to the lack of effective molecular-targeted drugs. To identify a novel therapeutic target for PDAC, we have performed genome-wide anamysis and found that Homo sapiens chromosome 16 open reading frame 74 (C16orf74) was up-regulated in the vast majority of PDAC. Overexpression of C16orf74protein detected by immunohistochemical analysis was an independent prognostic factor for patients with PDAC. The knockdown of endogenous C16orf74 expression in the PDAC cell lines KLM-1 and PK-59 by vector-based small hairpin-RNA (shRNA) drastically attenuated the growth of those cells, whereas ectopic C16orf74 overexpression in HEK293T and NIH3T3 cells promoted cell growth and invasion, respectively. More importantly, the endogenous threonine 44 (T44)-phosphorylated form of C16orf74 interacted with the protein phosphatase 3 catalytic subunit alpha (PPP3CA) via the PDIIIT sequence in the PPP3CA-binding motif within the middle portion of C16orf74 in PDAC cells. The overexpression of mutants of C16orf74 lacking the PDIIIT sequence or T44 phosphorylation resulted in the suppression of invasive activity compared with wild-type C16orf74, indicating that their interaction should be indispensable for PDAC cell invasion. These results suggest that C16orf74 plays an important role for PDAC invasion and proliferation, and is a promising target for a specific treatment for patients with PDAC. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Oncotarget (Impact Journals)
(eISSN: 1949-2553)
| ○ISSN (任意): | □ | 1949-2553
ISSN: 1949-2553
(eISSN: 1949-2553) Title: OncotargetTitle(ISO): OncotargetPublisher: Impact Journals LLC (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 8
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| ○号 (必須): | □ | 31
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| ○頁 (必須): | □ | 50460 50475
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 7月 28日 (平成 28年 7月 28日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.18632/oncotarget.10912 (→Scopusで検索)
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| ○PMID (任意): | □ | 28881575 (→Scopusで検索)
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| ○機関リポジトリ : | □ | 113051
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| ○備考 (任意): | 1. | (英) PublicationType: JOURNAL ARTICLE (日)
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