『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=316780)

EID=316780EID:316780, Map:0, LastModified:2018年5月23日(水) 17:07:05, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[田中 克哉], Read:継承, Write:継承, Delete:継承.
種別 (必須):
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kinoshita Michiko (日) (読)
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2. (英) Tsutsumi M. Yasuo (日) (読)
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[継承]
3. (英) Fukuta Kohei (日) (読)
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[継承]
4. (英) Kasai Asuka (日) (読)
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5.田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
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[継承]
題名 (必須): (英) Isoflurane-induced postconditioning via mitochondrial calcium-activated potassium channels.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Activation of the mitochondrial calcium-activated potassium (mKCa) channel reportedly confers resistance to myocardial ischemic stress. However, the role of the mKCa channel in postconditioning induced by volatile anesthetic remains unclear. Male Japanese white rabbits underwent coronary artery occlusion for 30 min followed by reperfusion for 3 h. Volatile anesthetic, isoflurane, was administered at 3 min prior to reperfusion for 5 min. Rabbits were injected with the mKCa channel blocker, iberiotoxin, or the mKCa channel opener, NS1619, at 8 min prior to reperfusion. Myocardial infarct size and the area at risk (AAR) were measured at the end of the experiment. Isoflurane significantly reduced infarct size (23.0 ± 9.8% of the AAR, P<0.05) compared with the control (44.0 ± 9.1%). Iberiotoxin abolished the cardioprotective impact of isoflurane (43.0 ± 11.6%), while iberiotoxin alone exerted no effect on infarct size (45.0 ± 9.5%). NS1619 and isoflurane/NS1619 both significantly reduced infarct size (21.0 ± 10.3% and 19.0 ± 8.8%, respectively, P<0.05 vs control group), but isoflurane/NS1619 showed no additional benefits compared with isoflurane alone. These results indicate that activation of the mKCa channel contribute isoflurane-induced postconditioning.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2016年 0月 初日 (平成 28年 0月 初日) [継承]
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DOI (任意): 10.2152/jmi.63.80    (→Scopusで検索) [継承]
PMID (任意): 27040058    (→Scopusで検索) [継承]
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機関リポジトリ : 111158 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.2152/jmi.63.80  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Michiko Kinoshita, Yasuo M. Tsutsumi, Kohei Fukuta, Asuka Kasai and Katsuya Tanaka : Isoflurane-induced postconditioning via mitochondrial calcium-activated potassium channels., The Journal of Medical Investigation : JMI, Vol.63, No.1-2, 80-84, (発行所), (都市), (month)2016.
欧文冊子 ● (種別) : Michiko Kinoshita, Yasuo M. Tsutsumi, Kohei Fukuta, Asuka Kasai and Katsuya Tanaka : Isoflurane-induced postconditioning via mitochondrial calcium-activated potassium channels., The Journal of Medical Investigation : JMI, Vol.63, No.1-2, 80-84, (発行所), (都市), (month)2016.

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