『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=316697)

EID=316697EID:316697, Map:0, LastModified:2018年12月13日(木) 11:22:47, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[安友 康二], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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2.佐々木 由紀 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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3.北村 明子 ([徳島大学.病院.先端医療開発研究プロジェクト]/[徳島大学.病院.診療科.小児·周産·女性科.小児科])
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4.安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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題名 (必須): (英) Differentiation of preadipocytes and mature adipocytes requires PSMB8.  (日)    [継承]
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要約 (任意): (英) The differentiation of adipocytes is tightly regulated by a variety of intrinsic molecules and also by extrinsic molecules produced by adjacent cells. Dysfunction of adipocyte differentiation causes lipodystrophy, which impairs glucose and lipid homeostasis. Although dysfunction of immunoproteasomes causes partial lipodystrophy, the detailed molecular mechanisms remain to be determined. Here, we demonstrate that Psmb8, a catalytic subunit for immunoproteasomes, directly regulates the differentiation of preadipocytes and additionally the differentiation of preadipocytes to mature adipocytes. Psmb8(-/-) mice exhibited slower weight gain than wild-type mice, and this was accompanied by reduced adipose tissue volume and smaller size of mature adipocytes compared with controls. Blockade of Psmb8 activity in 3T3-L1 cells disturbed the differentiation to mature adipocytes. Psmb8(-/-) mice had fewer preadipocyte precursors, fewer preadipocytes and a reduced ability to differentiate preadipocytes toward mature adipocytes. Our data demonstrate that Psmb8-mediated immunoproteasome activity is a direct regulator of the differentiation of preadipocytes and their ultimate maturation.  (日)    [継承]
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誌名 (必須): Scientific Reports ([Nature Publishing Group])
(eISSN: 2045-2322)

ISSN (任意): 2045-2322
ISSN: 2045-2322 (eISSN: 2045-2322)
Title: Scientific reports
Title(ISO): Sci Rep
Publisher: Nature Publishing Group
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 6 [継承]
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(必須): 26791 26791 [継承]
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年月日 (必須): 西暦 2016年 5月 26日 (平成 28年 5月 26日) [継承]
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DOI (任意): 10.1038/srep26791    (→Scopusで検索) [継承]
PMID (任意): 27225296    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-84971351712 [継承]
機関リポジトリ : 112317 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Hideki Arimochi, Yuki Sasaki, Akiko Kitamura and Koji Yasutomo : Differentiation of preadipocytes and mature adipocytes requires PSMB8., Scientific Reports, Vol.6, 26791, 2016.
欧文冊子 ● Hideki Arimochi, Yuki Sasaki, Akiko Kitamura and Koji Yasutomo : Differentiation of preadipocytes and mature adipocytes requires PSMB8., Scientific Reports, Vol.6, 26791, 2016.

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