| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
| [継承] |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Mayer CE (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Zuklys S (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Zhanybekova S (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | 大東 いずみ ([徳島大学.先端酵素学研究所.重点研究部門])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Teh HY (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Sansom SN (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Shikama-Dorn N (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Hafen K (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 9. | (英) Macaulay IC (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 10. | (英) Deadman ME (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 11. | (英) Ponting CP (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 12. | 高浜 洋介
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 13. | (英) Hollander GA (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Intrathymic T-cell development is critically dependent on cortical and medullary thymic epithelial cells (TECs). Both epithelial subsets originate during early thymus organogenesis from progenitor cells that express the thymoproteasome subunit β5t, a typical feature of cortical TECs. Using in vivo lineage fate mapping, we demonstrate in mice that β5t(+) TEC progenitors give rise to the medullary TEC compartment early in life but significantly limit their contribution once the medulla has completely formed. Lineage-tracing studies at single cell resolution demonstrate for young mice that the postnatal medulla is expanded from individual β5t(+) cortical progenitors located at the cortico-medullary junction. These results therefore not only define a developmental window during which the expansion of medulla is efficiently enabled by progenitors resident in the thymic cortex, but also reveal the spatio-temporal dynamics that control the growth of the thymic medulla. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
| [継承] |
| 2. | (英) Cell Differentiation (日) (読)
| [継承] |
| 3. | (英) Cell Lineage (日) (読)
| [継承] |
| 4. | (英) Cell Proliferation (日) (読)
| [継承] |
| 5. | (英) Doxycycline (日) (読)
| [継承] |
| 6. | (英) Epithelial Cells (日) (読)
| [継承] |
| 7. | (英) Mice (日) (読)
| [継承] |
| 8. | (英) Mice, Inbred C57BL (日) (読)
| [継承] |
| 9. | (英) Mice, Knockout (日) (読)
| [継承] |
| 10. | (英) Organogenesis (日) (読)
| [継承] |
| 11. | (英) Proteasome Endopeptidase Complex (日) (読)
| [継承] |
| 12. | (英) Stem Cells (日) (読)
| [継承] |
| 13. | (英) T-Lymphocytes (日) (読)
| [継承] |
| 14. | (英) Thymus Gland (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | European Journal of Immunology (European Federation of Immunological Societies)
(pISSN: 0014-2980, eISSN: 1521-4141)
| ○ISSN (任意): | □ | 1521-4141
ISSN: 0014-2980
(pISSN: 0014-2980, eISSN: 1521-4141) Title: European journal of immunologyTitle(ISO): Eur J ImmunolSupplier: European Federation of Immunological SocietiesPublisher: Wiley (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 46
| [継承] |
| ○号 (必須): | □ | 4
| [継承] |
| ○頁 (必須): | □ | 846 856
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 4月 初日 (平成 28年 4月 初日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1002/eji.201545995 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 26694097 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○Scopus (任意): |
| ○researchmap (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1002/eji.201545995 (日)
| [継承] |
| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
| [継承] |
| 4. | (英) OtherID: PMC4832341 (日)
| [継承] |
| 5. | (英) KeywordList.Keyword: Development (日)
| [継承] |
| 6. | (英) KeywordList.Keyword: Epithelial cell (日)
| [継承] |
| 7. | (英) KeywordList.Keyword: Medulla (日)
| [継承] |
| 8. | (英) KeywordList.Keyword: Thymic progenitor cell (日)
| [継承] |
| 9. | (英) KeywordList.Keyword: β5t (日)
| [継承] |