| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Oe Yuki (日) (読)
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| 2. | 馬場 麻人 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔顎顔面形態学])
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| 3. | (英) Ashida Hitoshi (日) (読)
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| 4. | (英) Nakamura Kouichi C (日) (読)
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| 5. | (英) Hirase Hajime (日) (読)
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| ○題名 (必須): | □ | (英) Glycogen distribution in the microwave-fixed mouse brain reveals heterogeneous astrocytic patterns. (日)
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| ○要約 (任意): | □ | (英) In the brain, glycogen metabolism has been implied in synaptic plasticity and learning, yet the distribution of this molecule has not been fully described. We investigated cerebral glycogen of the mouse by immunohistochemistry (IHC) using two monoclonal antibodies that have different affinities depending on the glycogen size. The use of focused microwave irradiation yielded well-defined glycogen immunoreactive signals compared with the conventional periodic acid-Schiff method. The IHC signals displayed a punctate distribution localized predominantly in astrocytic processes. Glycogen immunoreactivity (IR) was high in the hippocampus, striatum, cortex, and cerebellar molecular layer, whereas it was low in the white matter and most of the subcortical structures. Additionally, glycogen distribution in the hippocampal CA3-CA1 and striatum had a 'patchy' appearance with glycogen-rich and glycogen-poor astrocytes appearing in alternation. The glycogen patches were more evident with large-molecule glycogen in young adult mice but they were hardly observable in aged mice (1-2 years old). Our results reveal brain region-dependent glycogen accumulation and possibly metabolic heterogeneity of astrocytes. GLIA 2016;64:1532-1545. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Glia ([Wiley Periodicals, Inc.])
(pISSN: 0894-1491, eISSN: 1098-1136)
| ○ISSN (任意): | □ | 1098-1136
ISSN: 0894-1491
(pISSN: 0894-1491, eISSN: 1098-1136) Title: GliaTitle(ISO): GliaPublisher: Wiley (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 64
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | 1532 1545
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 6月 29日 (平成 28年 6月 29日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1002/glia.23020 (→Scopusで検索)
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| ○PMID (任意): | □ | 27353480 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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