| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Oboshi Wataru (日) (読)
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| 2. | (英) Watanabe Toru (日) (読)
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| 3. | (英) Yukimasa Nobuyasu (日) (読)
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| 4. | (英) Ueno Ichiro (日) (読)
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| 5. | 安藝 健作 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.細胞・免疫解析学])
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| 6. | (英) Tada Tomoki (日) 多田 智紀 (読) ただ ともき
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 7. | 細井 英司
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| ○題名 (必須): | □ | (英) SNPs rs4656317 and rs12071048 located within an enhancer in FCGR3A are in strong linkage disequilibrium with rs396991 and influence NK cell-mediated ADCC by transcriptional regulation. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) CD16 receptors are mainly expresses on the surface of NK cells and mediate antibody-dependent cellular cytotoxicity (ADCC). The authors previously reported that NK cell-mediated ADCC is influenced by the single nucleotide polymorphism (SNP) rs396991 (T>G; F158V), and the structure and expression levels of CD16 differed among these genotypes. The authors examined haplotype frequency distributions among rs396991 and other SNPs, rs10917571 (G>T), rs4656317 (C>G), and rs12071048 (G>A), located in an enhancer of the FCGR3A gene. A total of 101 healthy Japanese were genotyped for the presence of these SNPs. The authors also measured ADCC activity, FCGR3A transcript levels, and surface CD16 expression on NK cells. We found that the regulatory SNPs (rSNPs) rs4656317 and rs12071048 were in strong linkage disequilibrium with rs396991. These two SNPs with major alleles had higher ADCC activity than those with minor alleles. In addition, FCGR3A transcript levels and surface CD16 expression levels were regulated by these SNPs. These findings suggest that NK cell-mediated ADCC could be influenced by transcriptional regulation of these rSNPs. These findings help to clarify our understanding of the linkage disequilibrium among functional SNPs in the FCGR3A gene, and provide a resource for investigating the roles of functional SNPs in NK cell-mediated ADCC. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Human Immunology (American Association of Clinical Histocompatibility Testing/American Society for Histocompatibility and Immunogenetics)
(pISSN: 0198-8859, eISSN: 1879-1166)
| ○ISSN (任意): | □ | 1879-1166
ISSN: 0198-8859
(pISSN: 0198-8859, eISSN: 1879-1166) Title: Human immunologyTitle(ISO): Hum ImmunolPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 77
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| ○号 (必須): |
| ○頁 (必須): | □ | 997 1003
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 6月 20日 (平成 28年 6月 20日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.humimm.2016.06.012 (→Scopusで検索)
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) KeywordList.Keyword: Antibody-dependent cellular cytotoxicity (ADCC) (日)
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| 2. | (英) KeywordList.Keyword: Single nucleotide polymorphisms (SNPs) (日)
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