| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 石丸 善康 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.生物生産システム講座])
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| 2. | 友成 さゆり ([徳島大学.技術支援部.常三島技術部門])
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| 3. | (英) Matsuoka Yuji (日) (読)
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| 4. | 渡辺 崇人 ([徳島大学.バイオイノベーション研究所])
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| 5. | 宮脇 克行 ([徳島大学.バイオイノベーション研究所]/[徳島大学.生物資源産業学部.生物資源産業学科.生物生産システム講座])
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| 6. | (英) Bando Tetsuya (日) (読)
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| 7. | (英) Tomioka Kenji (日) (読)
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| 8. | (英) Ohuchi Hideyo (日) (読)
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| 9. | 野地 澄晴 ([徳島大学])
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| 10. | 三戸 太郎 ([徳島大学.バイオイノベーション研究所]/[徳島大学.生物資源産業学部.生物資源産業学科.生物生産システム講座])
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| ○題名 (必須): | □ | (英) TGF-β signaling in insects regulates metamorphosis via juvenile hormone biosynthesis. (日)
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| ○要約 (任意): | □ | (英) Although butterflies undergo a dramatic morphological transformation from larva to adult via a pupal stage (holometamorphosis), crickets undergo a metamorphosis from nymph to adult without formation of a pupa (hemimetamorphosis). Despite these differences, both processes are regulated by common mechanisms that involve 20-hydroxyecdysone (20E) and juvenile hormone (JH). JH regulates many aspects of insect physiology, such as development, reproduction, diapause, and metamorphosis. Consequently, strict regulation of JH levels is crucial throughout an insect's life cycle. However, it remains unclear how JH synthesis is regulated. Here, we report that in the corpora allata of the cricket, Gryllus bimaculatus, Myoglianin (Gb'Myo), a homolog of Drosophila Myoglianin/vertebrate GDF8/11, is involved in the down-regulation of JH production by suppressing the expression of a gene encoding JH acid O-methyltransferase, Gb'jhamt In contrast, JH production is up-regulated by Decapentaplegic (Gb'Dpp) and Glass-bottom boat/60A (Gb'Gbb) signaling that occurs as part of the transcriptional activation of Gb'jhamt Gb'Myo defines the nature of each developmental transition by regulating JH titer and the interactions between JH and 20E. When Gb'myo expression is suppressed, the activation of Gb'jhamt expression and secretion of 20E induce molting, thereby leading to the next instar before the last nymphal instar. Conversely, high Gb'myo expression induces metamorphosis during the last nymphal instar through the cessation of JH synthesis. Gb'myo also regulates final insect size. Because Myo/GDF8/11 and Dpp/bone morphogenetic protein (BMP)2/4-Gbb/BMP5-8 are conserved in both invertebrates and vertebrates, the present findings provide common regulatory mechanisms for endocrine control of animal development. (日)
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| ○誌名 (必須): | □ | Proceedings of the National Academy of Sciences of the United States of America ([The National Academy of Sciences of the United States of America])
(pISSN: 0027-8424, eISSN: 1091-6490)
| ○ISSN (任意): | □ | 1091-6490
ISSN: 0027-8424
(pISSN: 0027-8424, eISSN: 1091-6490) Title: Proceedings of the National Academy of Sciences of the United States of AmericaTitle(ISO): Proc Natl Acad Sci U S APublisher: National Academy of Sciences (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 113
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| ○号 (必須): | □ | 20
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| ○頁 (必須): | □ | 5634 5639
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 5月 2日 (平成 28年 5月 2日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1073/pnas.1600612113 (→Scopusで検索)
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| ○PMID (任意): | □ | 27140602 (→Scopusで検索)
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| ○Scopus (任意): | □ | 2-s2.0-84969765307
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1073/pnas.1600612113 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) OtherID: PMC4878498 (日)
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| 4. | (英) KeywordList.Keyword: GDF8/11 (日)
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| 5. | (英) KeywordList.Keyword: Gryllus bimaculatus (日)
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| 6. | (英) KeywordList.Keyword: RNA interference (日)
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| 7. | (英) KeywordList.Keyword: juvenile hormone (日)
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| 8. | (英) KeywordList.Keyword: metamorphosis (日)
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