| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Nagasato Daisuke (日) (読)
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| 2. | 三田村 佳典 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.眼科学])
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| 3. | 仙波 賢太郎
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| 4. | (英) Akaiwa Kei (日) (読)
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| 5. | 長澤 利彦
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| 6. | (英) Yoshizumi Yuki (日) (読)
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| 7. | (英) Tabuchi Hitoshi (日) (読)
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| 8. | (英) Kiuchi Yoshiaki (日) (読)
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| ○題名 (必須): | □ | (英) Correlation between optic nerve head circulation and visual function before and after anti-VEGF therapy for central retinal vein occlusion: prospective, interventional case series. (日)
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| ○要約 (任意): | □ | (英) To determine the correlation between the optic nerve head (ONH) circulation determined by laser speckle flowgraphy and the best-corrected visual acuity or retinal sensitivity before and after intravitreal bevacizumab or ranibizumab for central retinal vein occlusion. Thirty-one eyes of 31 patients were treated with intravitreal bevacizumab or ranibizumab for macular edema due to a central retinal vein occlusion. The blood flow in the large vessels on the ONH, the best-corrected visual acuity, and retinal sensitivity were measured at the baseline, and at 1, 3, and 6 months after treatment. The arteriovenous passage time on fluorescein angiography was determined. The venous tortuosity index was calculated on color fundus photograph by dividing the length of the tortuous retinal vein by the chord length of the same segment. The blood flow was represented by the mean blur rate (MBR) determined by laser speckle flowgraphy. To exclude the influence of systemic circulation and blood flow in the ONH tissue, the corrected MBR was calculated as MBR of ONH vessel area - MBR of ONH tissue area in the affected eye divided by the vascular MBR - tissue MBR in the unaffected eye. Pearson's correlation tests were used to determine the significance of correlations between the MBR and the best-corrected visual acuity, retinal sensitivity, arteriovenous passage time, or venous tortuosity index. At the baseline, the corrected MBR was significantly correlated with the arteriovenous passage time and venous tortuosity index (r = -0.807, P < 0.001; r = -0.716, P < 0.001; respectively). The corrected MBR was significantly correlated with the best-corrected visual acuity and retinal sensitivity at the baseline, and at 1, 3, and 6 months (all P < 0.050). The corrected MBR at the baseline was significantly correlated with the best-corrected visual acuity at 6 months (r = -0.651, P < 0.001) and retinal sensitivity at 6 months (r = 0.485, P = 0.005). The pre-treatment blood flow velocity of ONH can be used as a predictive factor for the best-corrected visual acuity and retinal sensitivity after anti-VEGF therapy for central retinal vein occlusion. UMIN000009072. Date of registration: 10/15/2012. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Aged (日) (読)
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| 3. | (英) Aged, 80 and over (日) (読)
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| 4. | (英) Angiogenesis Inhibitors (日) (読)
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| 5. | (英) Bevacizumab (日) (読)
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| 6. | (英) Blood Circulation (日) (読)
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| 7. | (英) Blood Flow Velocity (日) (読)
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| 8. | (英) Female (日) (読)
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| 9. | (英) Fluorescein Angiography (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | (英) Intravitreal Injections (日) (読)
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| 12. | (英) Laser-Doppler Flowmetry (日) (読)
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| 13. | (英) Male (日) (読)
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| 14. | (英) Middle Aged (日) (読)
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| 15. | (英) Optic Disk (日) (読)
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| 16. | (英) Prospective Studies (日) (読)
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| 17. | (英) Ranibizumab (日) (読)
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| 18. | (英) Retinal Vein Occlusion (日) (読)
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| 19. | (英) Tomography, Optical Coherence (日) (読)
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| 20. | (英) Vascular Endothelial Growth Factor A (日) (読)
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| 21. | (英) Visual Acuity (日) (読)
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| 22. | (英) Visual Field Tests (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | BMC Ophthalmology ([BioMed Central Ltd.])
(eISSN: 1471-2415)
| ○ISSN (任意): | □ | 1471-2415
ISSN: 1471-2415
(eISSN: 1471-2415) Title: BMC ophthalmologyTitle(ISO): BMC OphthalmolPublisher: BioMed Central (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 16
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 36 36
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 4月 5日 (平成 28年 4月 5日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1186/s12886-016-0211-7 (→Scopusで検索)
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| ○PMID (任意): | □ | 27044276 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-85008195243
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1186/s12886-016-0211-7 (日)
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| 2. | (英) Article.DataBankList.DataBank.DataBankName: JPRN (日)
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| 3. | (英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: UMIN000009072 (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 5. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 6. | (英) OtherID: PMC4820868 (日)
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| 7. | (英) KeywordList.Keyword: Anti-vascular endothelial growth factor agent (日)
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| 8. | (英) KeywordList.Keyword: Central retinal vein occlusion (日)
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| 9. | (英) KeywordList.Keyword: Fundus-related microperimetry (日)
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| 10. | (英) KeywordList.Keyword: Laser speckle flowgraphy (日)
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| 11. | (英) KeywordList.Keyword: Retinal blood flow (日)
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