| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない))
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| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Shindo Satoru (日) 進藤 智 (読) しんどう さとる
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 3. | 細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.⻭科保存学])
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| 4. | 尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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| 5. | 松尾 敬志
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| ○題名 (必須): | □ | (英) Shikonin Inhibits Inflammatory Cytokine Production in Human Periodontal Ligament Cells. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Shikonin, which is derived from Lithospermum erythrorhizon, a herb used in traditional medicine, has long been considered to be a useful treatment for various diseases in traditional oriental medicine. Shikonin has recently been reported to have several pharmacological properties, e.g., it has anti-microbial, anti-tumor, and anti-inflammatory effects. The aim of this study was to examine whether shikonin is able to influence the production of interleukin (IL)-6, IL-8, and/or chemokine C-C motif ligand (CCL)20, which contribute to the pathogenesis of periodontal disease, in human periodontal ligament cells (HPDLC). The production levels of IL-6, IL-8, and CCL20 in HPDLC were determined using an ELISA. Western blot analysis was used to detect nuclear factor kappa B (NF-B) pathway activation in HPDLC. Shikonin prevented IL-1- or tumor necrosis factor (TNF)--mediated IL-6, IL-8, and CCL20 production in HPDLC. Moreover, we found that shikonin suppressed the phosphorylation and degradation of inhibitor of kappa B-alpha (IB-) in IL-1- or TNF--stimulated HPDLC. These findings suggest that shikonin could have direct beneficial effects against periodontal disease by reducing IL-6, IL-8, and CCL20 production in periodontal lesions. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): | □ | Springer
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| ○誌名 (必須): | □ | Inflammation ([Springer-Verlag])
(pISSN: 0360-3997, eISSN: 1573-2576)
| ○ISSN (任意): | □ | 1573-2576
ISSN: 0360-3997
(pISSN: 0360-3997, eISSN: 1573-2576) Title: InflammationTitle(ISO): InflammationSupplier: Kluwer OnlinePublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 39
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 1124 1129
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 6月 初日 (平成 28年 6月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s10753-016-0344-0 (→Scopusで検索)
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| ○PMID (任意): | □ | 27072015 (→Scopusで検索)
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| ○機関リポジトリ : | □ | 112814
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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