| ○種別 (必須): | □ | 総説·解説
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Isaka Yoshitaka (日) (読)
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| 2. | (英) Takabatake Yoshitsugu (日) (読)
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| 3. | (英) Takahashi Atsushi (日) (読)
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| 4. | 齊藤 達哉
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| 5. | (英) Yoshimori Tamotsu (日) (読)
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| ○題名 (必須): | □ | (英) Hyperuricemia-induced inflammasome and kidney diseases. (日)
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| ○要約 (任意): | □ | (英) Classically, urate nephropathy has been postulated to cause kidney disease by depositing intraluminal crystal in the collecting duct. Recently, molecular mechanisms of inflammasome have been investigated. Urate-induced inflammasome pathway is comprised of urate crystal uptake into intracellular lysosomes and subsequent lysosomal rupture with mitochondrial reactive oxygen species (ROS) production, which activates the NLRP3 inflammasome. Against the lysosomal rupture and mitochondrial ROS production, autophagy acts to protect proximal tubular cells by isolating them from expanding the inflammation. In addition, increased cellular urate, directly or indirectly via xanthine oxidase-induced oxidative stress, may be associated with inflammasome. In addition to the traditional therapy against hyperuricemia, management of urate-induced inflammasome or augmentation of autophagy may offer the new effective therapies. (日)
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| ○誌名 (必須): | □ | Nephrology, Dialysis, Transplantation ([Oxford University Press])
(pISSN: 0931-0509, eISSN: 1460-2385)
| ○ISSN (任意): | □ | 1460-2385
ISSN: 0931-0509
(pISSN: 0931-0509, eISSN: 1460-2385) Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal AssociationTitle(ISO): Nephrol Dial TransplantSupplier: Oxford University PressPublisher: Oxford University Press (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 31
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 890 896
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| ○年月日 (必須): | □ | 西暦 2016年 6月 末日 (平成 28年 6月 末日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1093/ndt/gfv024 (→Scopusで検索)
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| ○PMID (任意): | □ | 25829326 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Review (日)
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